Mast Cell Regulation and Irritable Bowel Syndrome : Effects of Food Components with Potential Nutraceutical Use
Uranga, José Antonio (Universidad Rey Juan Carlos)
Martínez Perea, Vicente (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Abalo, Raquel (Universidad Rey Juan Carlos)

Data:	2020
Resum:	Mast cells are key actors in inflammatory reactions. Upon activation, they release histamine, heparin and nerve growth factor, among many other mediators that modulate immune response and neuron sensitization. One important feature of mast cells is that their population is usually increased in animal models and biopsies from patients with irritable bowel syndrome (IBS). Therefore, mast cells and mast cell mediators are regarded as key components in IBS pathophysiology. IBS is a common functional gastrointestinal disorder affecting the quality of life of up to 20% of the population worldwide. It is characterized by abdominal pain and altered bowel habits, with heterogeneous phenotypes ranging from constipation to diarrhea, with a mixed subtype and even an unclassified form. Nutrient intake is one of the triggering factors of IBS. In this respect, certain components of the daily food, such as fatty acids, amino acids or plant-derived substances like flavonoids, have been described to modulate mast cells' activity. In this review, we will focus on the effect of these molecules, either stimulatory or inhibitory, on mast cell degranulation, looking for a nutraceutical capable of decreasing IBS symptoms.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Cannabidiol ; Fatty acids ; Heparin ; Histamine ; Irritable bowel syndrome ; Mast cells ; Nerve growth factor ; Nutraceuticals ; Polyphenols ; Visceral pain
Publicat a:	Molecules, Vol. 25 (september 2020) , ISSN 1420-3049

DOI: 10.3390/molecules25184314
PMID: 32962285

30 p, 747.4 KB

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