Altered GDF15 and FGF21 Levels in Response to Strenuous Exercise : A Study in Marathon Runners
Campderrós, Laura (Universitat de Barcelona)
Sánchez-Infantes, David (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Villarroya, Joan (Universitat de Barcelona)
Nescolarde, Lexa (Universitat Politècnica de Catalunya)
Bayés-Genís, Antoni (Universitat Autònoma de Barcelona. Departament de Medicina)
Cereijo, Rubén (Universitat de Barcelona)
Roca, Emma (Universitat Politècnica de Catalunya)
Villarroya, Francesc (Universitat de Barcelona)

Fecha:	2020
Resumen:	Recreational marathon runners face strong physiological challenges. Assessment of potential biomarkers for the biological responses of runners will help to discriminate individual race responsiveness and their physiological consequences. This study sought to analyze the changes in the plasma levels of GDF15 and FGF21, novel endocrine factors related to metabolic stress, in runners following the strenuous exercise of a marathon race. Blood samples were obtained from eighteen male runners (mean ±SD, age: 41. 7 ±5. 0 years, BMI: 23. 6 ± 1. 8) 48 h before, immediately after, and 48 h after a marathon race, and from age-matched sedentary individuals. The level of GDF15, FGF21, and 38 additional biochemical and hematological parameters were determined. The basal levels of GDF15 and FGF21 did not differ between runners before the race and sedentary individuals. Significant increases in the mean levels of GDF15 (4. 2-fold) and FGF21 (20-fold) were found in runners immediately after the race. The magnitudes of these increases differed markedly among individuals and did not correlate with each other. The GDF15 and FGF21 levels had returned to the basal level 48 h post-race. The post-race value of GDF15 (but not FGF21) correlated positively with increased total white cell count (r = 0. 50, P = 0. 01) and neutrophilia (r = 0. 10, P = 0. 01). GDF15 and FGF21 are transiently increased in runners following a marathon race. The induction of GDF15 levels is associated with alterations in circulating immune cells levels.
Ayudas:	Agencia Estatal de Investigación SAF2017-85722-R Instituto de Salud Carlos III FIS17/01455
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Strenuous exercise ; GDF15 ; FGF21 ; Marathon athletes ; Biomarker
Publicado en:	Frontiers in physiology, Vol. 11 (november 2020) , ISSN 1664-042X

DOI: 10.3389/fphys.2020.550102
PMID: 33329017

8 p, 530.2 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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