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Página principal > Artículos > Artículos publicados > The Tryptophan System in Cocaine-Induced Depression |
Fecha: | 2020 |
Resumen: | Major depression disorder (MDD) is the most prevalent psychiatric comorbid condition in cocaine use disorder (CUD). The comorbid MDD might be primary-MDD (CUD-primary-MDD) or cocaine-induced MDD (CUD-induced-MDD), and their accurate diagnoses and treatment is a challenge for improving prognoses. This study aimed to assess the tryptophan/serotonin (Trp/5-HT) system with the acute tryptophan depletion test (ATD), and the kynurenine pathway in subjects with CUD-primary-MDD, CUD-induced-MDD, MDD and healthy controls. The ATD was performed with a randomized, double-blind, crossover, and placebo-controlled design. Markers of enzymatic activity of indoleamine 2,3-dioxygenase/tryptophan 2,3-dioxygenase, kynurenine aminotransferase (KAT) and kynureninase were also established. Following ATD, we observed a decrease in Trp levels in all groups. Comparison between CUD-induced-MDD and MDD revealed significant differences in 5-HT plasma concentrations (512 + 332 ng/mL vs. 107 + 127 ng/mL, p = 0. 039) and the Kyn/5-HT ratio (11 + 15 vs. 112 + 136; p = 0. 012), whereas there were no differences between CUD-primary-MDD and MDD. Effect size coefficients show a gradient for all targeted markers (d range 0. 72-1. 67). Results suggest different pathogenesis for CUD-induced-MDD, with lower participation of the tryptophan system, probably more related to other neurotransmitter pathways and accordingly suggesting the need for a different pharmacological treatment approach. |
Ayudas: | Ministerio de Economía y Competitividad RD16/0017/0010 Ministerio de Economía y Competitividad RD16/0017/0003 Ministerio de Economía y Competitividad PI14/00178 Ministerio de Economía y Competitividad PI16/00603 Ministerio de Economía y Competitividad JR 16/00020 Ministerio de Economía y Competitividad 2012I054 Ministerio de Economía y Competitividad MTM2015-64465-C2-1-R |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Primary/substance-induced depression ; Cocaine use disorder ; Tryptophan ; Serotonin ; Kynurenine |
Publicado en: | Journal of clinical medicine, Vol. 9 (december 2020) , ISSN 2077-0383 |
14 p, 1.4 MB |