Interaction between FKBP5 variability and recent life events in the anxiety spectrum : Evidence for the differential susceptibility model
Pérez-Pérez, Beatriz (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Cristóbal Narváez, Paula (Centro de Investigación Biomédica en Red de Salud Mental)
Sheinbaum Frank, Tamara (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Kwapil, Thomas R. (University of Illinois. Department of Psychology)
Ballespí Sola, Sergi (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Peña, Elionora (Universitat de Barcelona. Institut de Biomedicina)
De Castro-Catala, Marta (Universitat de Barcelona. Institut de Biomedicina)
Riba, Maria Dolors (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Rosa, Araceli (Universitat de Barcelona. Institut de Biomedicina)
Barrantes-Vidal, Neus (Sant Pere Claver-Fundació Sanitària)

Fecha:	2018
Resumen:	Gene-environment interaction (GxE) research has highlighted the importance of investigating the FK506 binding protein 51 (FKBP5) gene as a sensitivity gene. However, previous GxE studies with FKBP5 have not measured the full environmental spectrum or applied statistical tests to discern whether the GxE interaction fits better with the differential-susceptibility or diathesis-stress hypotheses. This study examined whether single nucleotide polymorphisms (SNPs) on FKBP5 gene moderate the association of positive and negative recent life events (LEs) with depressive symptoms, state-anxiety, neuroticism, and social anxiety traits. A total of 86 nonclinical young adults were administered psychological measures and were genotyped for five FKBP5 SNPs (rs3800373, rs9296158, rs1360780, rs9470080 and rs4713916). Regression analyses indicated significant GxE interactions for social anxiety and neuroticism. The interactions predicting neuroticism fit different models for different SNPs, although the overall effect indicated by the haplotype was consistent with the differential-susceptibility hypothesis: the risk-haplotype group presented higher neuroticism in the presence of more negative LEs and lower neuroticism in the presence of more positive LEs. The GxE interactions for social anxiety were consistent with the diathesis-stress model. The lack of significance in the for-better side for social anxiety might be related to the fact that it mapped onto low extraversion, which is associated with a lower permeability to positive experiences. Findings underscore the importance of testing the differential-susceptibility model in relation to FKBP5 to adequately characterize its role in healthy and pathological developmental processes.
Ayudas:	Ministerio de Economía y Competitividad PSI2011-30321-C02-01 Ministerio de Economía y Competitividad PSI2011-30321-C02-02 Ministerio de Economía y Competitividad PSI2014-54009-R Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-1636 Agència de Gestió d'Ajuts Universitaris i de Recerca 2014-SGR-1070 Fundació la Marató de TV3 091110
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Publicado en:	PloS one, Vol. 13 (february 2018) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0193044
PMID: 29466454

14 p, 3.6 MB

El registro aparece en las colecciones:
Artículos > Artículos de investigación
Artículos > Artículos publicados