The prostaglandin D receptor 2 pathway in asthma : a key player in airway inflammation
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Palomares, Oscar (Complutense University of Madrid. Department of Biochemistry and Molecular Biology)
Sandham, David A. (Novartis Institutes for Biomedical Research)
Erpenbeck, Veit J. (Novartis Pharma)
Altman, Pablo (Novartis Pharmaceuticals Corporation (Estats Units d'Amèrica))
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	Asthma is characterised by chronic airway inflammation, airway obstruction and hyper-responsiveness. The inflammatory cascade in asthma comprises a complex interplay of genetic factors, the airway epithelium, and dysregulation of the immune response. Prostaglandin D (PGD) is a lipid mediator, predominantly released from mast cells, but also by other immune cells such as T2 cells and dendritic cells, which plays a significant role in the pathophysiology of asthma. PGD mainly exerts its biological functions via two G-protein-coupled receptors, the PGD receptor 1 (DP) and 2 (DP). The DP receptor is mainly expressed by the key cells involved in type 2 immune responses, including T2 cells, type 2 innate lymphoid cells and eosinophils. The DP receptor pathway is a novel and important therapeutic target for asthma, because increased PGD production induces significant inflammatory cell chemotaxis and degranulation via its interaction with the DP receptor. This interaction has serious consequences in the pulmonary milieu, including the release of pro-inflammatory cytokines and harmful cationic proteases, leading to tissue remodelling, mucus production, structural damage, and compromised lung function. This review will discuss the importance of the DP receptor pathway and the current understanding of its role in asthma.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Asthma ; Airway inflammation ; Prostaglandin D ; Prostaglandin D receptor 2
Published in:	Respiratory Research, Vol. 19 (september 2018) , ISSN 1465-993X

DOI: 10.1186/s12931-018-0893-x
PMID: 30268119

8 p, 735.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles