Influence of HLA-B27 on the Ankylosing Spondylitis phenotype : results from the REGISPONSER database
Arévalo Salaet, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Gratacós, Jordi (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Moreno Martínez-Losa, Mireia (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Calvet, Joan (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Orellana, Cristóbal (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Ruiz, Desirée (Instituto Maimónides de Investigación Biomédica de Córdoba)
Castro, Carmen (Instituto Maimónides de Investigación Biomédica de Córdoba)
Carreto, Pilar (Instituto Maimónides de Investigación Biomédica de Córdoba)
Larrosa, Marta (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Collantes Estevéz, Eduardo (Instituto Maimónides de Investigación Biomédica de Córdoba)
Font, Pilar (Instituto Maimónides de Investigación Biomédica de Córdoba)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	To assess HLA-B27 influence on the clinical phenotype of Ankylosing Spondylitis (AS) patients. An observational, cross-sectional and descriptive study of AS patients from the Spanish REGISPONSER database was performed. Demographic, clinical, disease activity (Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), Bath Ankylosing Spondylitis Functional Index (BASFI), erythrocyte sedimentation rate (ESR), and C-reactive protein (CRP)), and radiographic data (Bath Ankylosing Spondylitis Radiology Index (BASRI) score) were compared regarding HLA-B27 status. A univariate and multivariate analysis was performed to identify variables independently related to the presence of HLA-B27. Data from 1235 patients (74. 8% male) were analyzed; 1029 were HLA-B27 positive (83%). HLA-B27-positive patients showed higher family aggregation and an earlier onset of disease compared with those who were HLA-B27 negative. HLA-B27-negative patients presented statistically higher BASDAI and BASFI scores and higher prevalence of arthritis, dactylitis, and extra-articular manifestations (psoriasis and inflammatory bowel disease (IBD)) but not anytime uveitis compared with those who were HLA-B27 positive. In the multivariate analysis, family history (odds ratio (OR) 2. 10, 95% confidence interval (CI) 1. 27-3. 49), younger age at diagnosis (OR 0. 97, 95% CI 0. 96-0. 98), presence of peripheral arthritis (OR 0. 53, 95% CI 0. 32-0. 89), dactylitis (OR 0. 16, 95% CI 0. 05-0. 56), psoriasis (OR 0. 45, 95% CI 0. 26-0. 78), and IBD (OR 0. 22, 95% CI 0. 12-0. 40) were the main variables independently related to the presence or not of HLA-B27. In Caucasian AS patients, the presence of HLA-B27 is related to an earlier disease onset and higher family aggregation. Absence of HLA-B27 is related to a higher frequency of peripheral arthritis, dactylitis, and extra-articular manifestations. Being HLAB27 positive is not related to a higher burden of disease or anytime uveitis.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Ankylosing Spondylitis ; HLA-B27 ; Structural damage ; Phenotype ; Uveitis
Published in:	Arthritis research & therapy, Vol. 20 (october 2018) , ISSN 1478-6362

DOI: 10.1186/s13075-018-1724-7
PMID: 30285828

6 p, 435.0 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles