Quantitative videocapillaroscopy correlates with functional respiratory parameters : a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis
Guillén-Del-Castillo, Alfredo (Hospital Universitari Vall d'Hebron)
Simeón-Aznar, Carmen Pilar (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Callejas Moraga, Eduardo Luis (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Tolosa-Vilella, Carles (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Alonso Vila, Serafín (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Fonollosa Pla, Vicent (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Selva O'Callaghan, Albert (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2018
Abstract:	To determine whether lung involvement is related to microvascular perturbations, nailfold videocapillaroscopy (NVC) was performed in patients with systemic sclerosis (SSc). A cross-sectional study was consecutively accomplished in 152 SSc patients. NVC, a pulmonary function test and echocardiography were undergone within a 3-month period. Finally, 134 patients with at least eight NVC (200× magnification) images were selected for quantitative and qualitative examinations. Patients with interstitial lung disease presented lower median capillary density (4. 86/mm vs 5. 88/mm, p = 0. 005) and higher median of neoangiogenesis (0. 56/mm vs 0. 31/mm, p = 0. 005). A higher quantity of neoangiogenesis capillaries was found in patients with pulmonary arterial hypertension (0. 70/mm vs 0. 33/mm, p = 0. 008). Multivariate linear regression analysis established a correlation between neoangiogenesis and decreased forced vital capacity (FVC) (p < 0. 001): for each capillary with neoangiogenesis visualized on average per 1 mm, FVC was 7. 3% reduced. In qualitative NVC, a late pattern as defined by Cutolo was also associated with lower FVC (p = 0. 018). The number of giant capillaries was associated with reduced diffusion capacity of the lung for carbon monoxide (DLCO) (p = 0. 016); for each giant capillary per 1 mm, DLCO was 11. 8% diminished. A good correlation was observed between distinctive quantitative and qualitative NVC features with lung functional parameters such as FVC and DLCO. It is suggested that vasculopathy could play a role in SSc lung involvement.
Grants:	Ministerio de Economía, Industria y Competitividad PI15/02100 Ministerio de Economía, Industria y Competitividad PI16/02088
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Interstitial lung disease ; Nailfold videocapillaroscopy ; Pulmonary hypertension ; Scleroderma ; Systemic sclerosis
Published in:	Arthritis research & therapy, Vol. 20 (december 2018) , ISSN 1478-6362

DOI: 10.1186/s13075-018-1775-9
PMID: 30567570

10 p, 719.2 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles