Influence of early neurological complications on clinical outcome following lung transplant
Gamez, Josep (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Salvado, Maria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Martinez-de La Ossa, Alejandro (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Deu, Maria (Hospital Universitari Vall d'Hebron)
Romero, Laura (Hospital Universitari Vall d'Hebron)
Roman, Antonio (Hospital Universitari Vall d'Hebron)
Sacanell, Judith (Hospital Universitari Vall d'Hebron)
Laborda, César (Hospital Universitari Vall d'Hebron)
Rochera, Isabel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Nadal Clanchet, Miriam de (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Carmona Jiménez, Francesc (Universitat de Barcelona. Departament d'Estadística)
Santamarina, Estevo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Raguer, Nuria (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Canela, Mercedes (Hospital Universitari Vall d'Hebron)
Solé, Joan (Hospital Universitari Vall d'Hebron)
Universitat Autònoma de Barcelona

Date:	2017
Abstract:	Neurological complications after lung transplantation are common. The full spectrum of neurological complications and their impact on clinical outcomes has not been extensively studied. We investigated the neurological incidence of complications, categorized according to whether they affected the central, peripheral or autonomic nervous systems, in a series of 109 patients undergoing lung transplantation at our center between January 1 2013 and December 31 2014. Fifty-one patients (46. 8%) presented at least one neurological complication. Critical illness polyneuropathy-myopathy (31 cases) and phrenic nerve injury (26 cases) were the two most prevalent complications. These two neuromuscular complications lengthened hospital stays by a median period of 35. 5 and 32. 5 days respectively. However, neurological complications did not affect patients' survival. The real incidence of neurological complications among lung transplant recipients is probably underestimated. They usually appear in the first two months after surgery. Despite not affecting mortality, they do affect the mean length of hospital stay, and especially the time spent in the Intensive Care Unit. We found no risk factor for neurological complications except for long operating times, ischemic time and need for transfusion. It is necessary to develop programs for the prevention and early recognition of these complications, and the prevention of their precipitant and risk factors.
Grants:	Ministerio de Economía y Competitividad PI13-01272
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan aquestes es distribueixin sota la mateixa llicència que regula l'obra original i es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	PloS one, Vol. 12 (march 2017) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0174092
PMID: 28301586

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