Peripheral blood metabolic and inflammatory factors as biomarkers to ocular findings in diabetic macular edema
Figueras-Roca, Marc (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Molins, Blanca (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Sala-Puigdollers, Anna (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Matas, Jessica (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Vinagre, Irene (Hospital Clínic i Provincial de Barcelona)
Ríos, José (Universitat Autònoma de Barcelona. Departament de Pediatria, Obstetrícia i Ginecologia i Medicina Preventiva i Salut Pública)
Adan Civera, Alfredo (Institut d'Investigacions Biomèdiques August Pi i Sunyer)

Data:	2017
Resum:	To study the association between peripheral blood metabolic and inflammatory factors and presence of diabetic macular edema (DME) and its related anatomic features in type 2 diabetic mellitus (T2DM) patients. Observational cross-sectional study on a proof of concept basis. Seventy-six T2DM included patients were divided based on the presence (n = 58) or absence of DME (n = 18) according to optical coherence tomography (OCT). Ultra-widefield fluorescein angiography (UWFA) was performed in DME patients. Fasting peripheral blood sample testing included glycemia, glycated hemoglobin, creatinin and lipid levels among others. Serum levels of a broad panel of cytokines and inflammatory mediators were also analysed. OCT findings included central subfoveal thickness, diffuse retinal thickness (DRT), cystoid macular edema (CME), serous retinal detachment and epirretinal membrane. UWFA items included pattern of DME, presence of peripheral retinal ischemia and enlarged foveal avascular zone (FAZ). Metabolic and inflammatory factors did not statistically differ between groups. However, several inflammatory mediators did associate to certain ocular items of DME cases: IL-6 was significantly higher in patients with DRT (p = 0. 044), IL-10 was decreased in patients with CME (p = 0. 012), and higher IL-8 (p = 0. 031) and VEGF levels (p = 0. 031) were observed in patients with enlarged FAZ. Inflammatory and metabolic peripheral blood factors in T2DM may not be differentially associated to DME when compared to non-DME cases. However, some OCT and UWFA features of DME such as DRT, CME and enlarged FAZ may be associated to certain systemic inflammatory mediators.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 12 (march 2017) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0173865
PMID: 28328965

13 p, 1.6 MB

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