Prevalence, evolution, and related risk factors of kidney disease among Spanish HIV-infected individuals
Juega-Mariño, Javier (Universitat Autònoma de Barcelona. Departament de Medicina)
Bonjoch, Anna (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Pérez-Álvarez, Núria (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Negredo Puigmal, Eugènia (Institut Germans Trias i Pujol. Fundació de Lluita Contra la Sida)
Bayés Genís, Beatriu (Institut Germans Trias i Pujol. Hospital Universitari Germans Trias i Pujol)
Bonet Sol, Josep (Universitat Autònoma de Barcelona)
Clotet Sala, Bonaventura (Institut Germans Trias i Pujol. Institut de Recerca de la Sida IrsiCaixa)
Romero, Ramon (Universitat Autònoma de Barcelona. Departament de Medicina)

Fecha:	2017
Resumen:	Prevalence of kidney disease (KD) is increasing among human immunodeficiency virus (HIV)-infected population. Different factors have been related, varying on different published series. The objectives were to study prevalence of KD in those patients, its evolution, and associated risk factors. An observational cohort study of 1596 HIV-positive patients with cross-sectional data collection in 2008 and 2010 was conducted. We obtained clinical and laboratory markers, and registered previous or current treatment with tenofovir (TDF) and indinavir (IDV). The sample was divided according to estimated glomerular filtration rate (eGFR) by modification of diet in renal disease (MDRD) equation. Group 1: eGFR ≤60 mL/min/1. 73 m 2 ; group 2: eGFR >60 mL/min/1. 73 m 2. Among the patients, 76. 4% were men, mean age (SD) 45 ± 9 years, time since diagnose of HIV 14 ± 7 years, and 47. 2% of the patients received previous treatment with TDF and 39. 1% with IDV. In 2008, eGFR ≤60: 4. 9% (91. 4% of them in chronic kidney disease [CKD] stage 3, eGFR 59-30 mL/min); this group was older, presented higher fibrinogen levels, and more patients were treated previously with TDF and IDV. In 2010, eGFR ≤60: 3. 9% (87. 1% stage 3 CKD). The 2. 4% of cohort showed renal improvement and 1. 3% decline of renal function over time. The absence of hypertension and treatment with TDF were associated with improvement in eGFR. Increased age, elevated fibrinogen, decreased albumin, diabetes mellitus, hyperTG, and worse virological control were risk factors for renal impairment. The HIV-positive patients in our area have a CKD prevalence of 4% to 5% (90% stage 3 CKD) associated with ageing, inflammation, worse immune control of HIV, TDF treatment, and metabolic syndrome.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Chronic kidney disease ; Epidemiology ; HIV ; Human immunodeficiency virus ; Tenofovir
Publicado en:	Medicine, Vol. 96 (september 2017) , ISSN 1536-5964

DOI: 10.1097/MD.0000000000007421
PMID: 28906351

8 p, 254.6 KB

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Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut d'Investigació en Ciencies de la Salut Germans Trias i Pujol (IGTP)
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