Mucosal immunoglobulins at respiratory surfaces mark an ancient association that predates the emergence of tetrapods
Xu, Zhen (Huazhong Agricultural University. Department of Aquatic Animal Medicine)
Takizawa, Fumio (University of Pennsylvania. Department of Pathobiology)
Parra, David (Universitat Autònoma de Barcelona. Departament de Biologia Cel·lular, de Fisiologia i d'Immunologia)
Gómez, Daniela (University of Pennsylvania. Department of Pathobiology)
von Gersdorff Jørgensen, Louise (University of Copenhagen. Department of Veterinary Disease Biology)
LaPatra, Scott E. (Clear Springs Foods Inc)
Sunyer, J. Oriol (University of Pennsylvania. Department of Pathobiology)

Data:	2016
Resum:	Gas-exchange structures are critical for acquiring oxygen, but they also represent portals for pathogen entry. Local mucosal immunoglobulin responses against pathogens in specialized respiratory organs have only been described in tetrapods. Since fish gills are considered a mucosal surface, we hypothesized that a dedicated mucosal immunoglobulin response would be generated within its mucosa on microbial exposure. Supporting this hypothesis, here we demonstrate that following pathogen exposure, IgT+ B cells proliferate and generate pathogen-specific IgT within the gills of fish, thus providing the first example of locally induced immunoglobulin in the mucosa of a cold-blooded species. Moreover, we demonstrate that gill microbiota is predominantly coated with IgT, thus providing previously unappreciated evidence that the microbiota present at a respiratory surface of a vertebrate is recognized by a mucosal immunoglobulin. Our findings indicate that respiratory surfaces and mucosal immunoglobulins are part of an ancient association that predates the emergence of tetrapods.
Ajuts:	European Commission 311993
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Nature communications, Vol. 7 (February 2016) , art. 10728, ISSN 2041-1723

DOI: 10.1038/ncomms10728
PMID: 26869478

14 p, 2.9 MB

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