Endothelial Progenitor Cells Predict Cardiovascular Events after Atherothrombotic Stroke and Acute Myocardial Infarction. A PROCELL Substudy
Cuadrado-Godia, Elisa (Institut Hospital del Mar d'Investigacions Mèdiques)
Regueiro, Ander (Hospital Clínic i Provincial de Barcelona)
Núñez, Julio (Hospital Clínic Universitari (València))
Diaz-Ricart, Maribel (Hospital Clínic i Provincial de Barcelona)
Novella, Susana (Hospital Clínic Universitari (València))
Oliveras, Anna (Universitat Autònoma de Barcelona. Departament de Medicina)
Valverde, Miguel A. (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Marrugat, Jaume 1954- (Institut Hospital del Mar d'Investigacions Mèdiques)
Ois, Angel (Universitat Autònoma de Barcelona. Departament de Medicina)
Giralt Steinhauer, Eva (Institut Hospital del Mar d'Investigacions Mèdiques)
Sanchís, Juan (Hospital Clínic Universitari (València))
Escolar, Ginès (Hospital Clínic i Provincial de Barcelona)
Hermenegildo, Carlos (Hospital Clínic Universitari (València))
Heras, Magda (Hospital Clínic i Provincial de Barcelona)
Roquer, Jaume (Institut Hospital del Mar d'Investigacions Mèdiques)

Data:	2015
Resum:	The aim of this study was to determine prognostic factors for the risk of new vascular events during the first 6 months after acute myocardial infarction (AMI) or atherothrombotic stroke (AS). We were interested in the prognostic role of endothelial progenitor cells (EPC) and circulating endothelial cells (CEC) Between February 2009 and July 2012, 100 AMI and 50 AS patients were consecutively studied in three Spanish centres. Patients with previously documented coronary artery disease or ischemic strokes were excluded. Samples were collected within 24h of onset of symptoms. EPC and CEC were studied using flow cytometry and categorized by quartiles. Patients were followed for up to 6 months. NVE was defined as new acute coronary syndrome, transient ischemic attack (TIA), stroke, or any hospitalization or death from cardiovascular causes. The variables included in the analysis included: vascular risk factors, carotid intima-media thickness (IMT), atherosclerotic burden and basal EPC and CEC count. Multivariate survival analysis was performed using Cox regression analysis. During follow-up, 19 patients (12. 66%) had a new vascular event (5 strokes; 3 TIAs; 4 AMI; 6 hospitalizations; 1 death). Vascular events were associated with age (P = 0. 039), carotid IMT≥0. 9 (P = 0. 044), and EPC count (P = 0. 041) in the univariate analysis. Multivariate Cox regression analysis showed an independent association with EPC in the lowest quartile (HR: 10. 33, 95%CI (1. 22-87. 34), P = 0. 032] and IMT≥0. 9 [HR: 4. 12, 95%CI (1. 21-13. 95), P = 0. 023]. Basal EPC and IMT≥0. 9 can predict future vascular events in patients with AMI and AS, but CEC count does not affect cardiovascular risk.
Ajuts:	Ministerio de Economía y Competitividad RD12/0042/0010 Ministerio de Economía y Competitividad RD12/0042/0052
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 10 (september 2015) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0132415
PMID: 26332322

13 p, 312.7 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats