Moderate-Vigorous Physical Activity across Body Mass Index in Females : Moderating Effect of Endocannabinoids and Temperament
Fernández-Aranda, Fernando (Universitat de Barcelona. Departament de Ciències Clíniques)
Sauchelli, Sarah (Institut d'Investigació Biomèdica de Bellvitge)
Pastor, Antoni (Institut Hospital del Mar d'Investigacions Mèdiques)
Gonzalez, Marcela L. (Universitat Rovira i Virgili. Departament de Psicologia)
De La Torre, Rafael (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Granero, Roser (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Jiménez-Murcia, Susana (Universitat de Barcelona. Departament de Ciències Clíniques)
Baños, Rosa (University of Valencia. Department of Psychological, Personality, Evaluation and Treatment)
Botella, Cristina (Universitat Jaume I. Departament de Psicologia Bàsica, Clínica i Psicobiologia)
Fernández Real, Jose Manuel (Institut d'Investigació Biomèdica de Girona)
Fernández-García, Jose C. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Frühbeck, Gema (University of Navarra. Department of Endocrinology and Nutrition)
Gómez-Ambrosi, Javier (University of Navarra. Department of Endocrinology and Nutrition)
Rodríguez, Roser (Institut d'Investigació Biomèdica de Girona)
Tinahones, Francisco J.. (Hospital Universitario Virgen de la Victoria (Màlaga, Andalusia))
Arcelus, Jon (Glenfield University Hospital (United Kingdom). Eating Disorders Service)
Fagundo, Ana B. (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Agüera, Zaida (Centro de Investigación Biomédica en Red de Fisiopatología de la Obesidad y Nutrición)
Miró, Jordi (Universitat Pompeu Fabra. Departament de Ciències Experimentals i de la Salut)
Casanueva, Felipe F.. (Santiago de Compostela University. Department of Medicine, Endocrinology Division)

Data:	2014
Resum:	Endocannabinoids and temperament traits have been linked to both physical activity and body mass index (BMI) however no study has explored how these factors interact in females. The aims of this cross-sectional study were to 1) examine differences among distinct BMI groups on daytime physical activity and time spent in moderate-vigorous physical activity (MVPA), temperament traits and plasma endocannabinoid concentrations; and 2) explore the association and interaction between MVPA, temperament, endocannabinoids and BMI. Physical activity was measured with the wrist-worn accelerometer Actiwatch AW7, in a sample of 189 female participants (43 morbid obese, 30 obese, and 116 healthy-weight controls). The Temperament and Character Inventory-Revised questionnaire was used to assess personality traits. BMI was calculated by bioelectrical impedance analysis via the TANITA digital scale. Blood analyses were conducted to measure levels of endocannabinoids and endocannabinoid-related compounds. Path-analysis was performed to examine the association between predictive variables and MVPA. Obese groups showed lower MVPA and dysfunctional temperament traits compared to healthy-weight controls. Plasma concentrations of 2-arachidonoylglyceryl (2-AG) were greater in obese groups. Path-analysis identified a direct effect between greater MVPA and low BMI (b = −0. 13, p = . 039) and high MVPA levels were associated with elevated anandamide (AEA) levels (b = 0. 16, p = . 049) and N -oleylethanolamide (OEA) levels (b = 0. 22, p = . 004), as well as high Novelty seeking (b = 0. 18, p <. 001) and low Harm avoidance (b = −0. 16, p <. 001). Obese individuals showed a distinct temperament profile and circulating endocannabinoids compared to controls. Temperament and endocannabinoids may act as moderators of the low MVPA in obesity.
Ajuts:	Agència de Gestió d'Ajuts Universitaris i de Recerca 2009-SGR-718
Nota:	Altres ajuts: This manuscript was supported by grants from Instituto Salud Carlos III (FIS PI11/210 and CIBERobn). Sarah Sauchelli is recipient of a pre-doctoral Grant (2013-17) by IDIBELL. Jose C. Fernández-García is recipient of a 'Rio Hortega' contract from 'Instituto de Salud Carlos III', Madrid, Spain (CM12/00059). The funders had no role in the study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	PloS one, Vol. 9 núm. 8 (2014) , ISSN 1932-6203

DOI: 10.1371/journal.pone.0104534
PMID: 25101961

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