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| Home > Articles > Published articles > Hsp70 Regulates Immune Response in Experimental Autoimmune Encephalomyelitis |
(Universitat Autònoma de Barcelona) (Universitat Autònoma de Barcelona) (Universitat Autònoma de Barcelona) (Universitat Autònoma de Barcelona) (University Hospital Zurich (Suïssa)) (Universitat Autònoma de Barcelona) (Universitat Autònoma de Barcelona)
| Date: | 2014 |
| Abstract: | Heat shock protein (Hsp)70 is one of the most important stress-inducible proteins. Intracellular Hsp70 not only mediates chaperone-cytoprotective functions but can also block multiple steps in the apoptosis pathway. In addition, Hsp70 is actively released into the extracellular milieu, thereby promoting innate and adaptive immune responses. Thus, Hsp70 may be a critical molecule in multiple sclerosis (MS) pathogenesis and a potential target in this disease due to its immunological and cytoprotective functions. To investigate the role of Hsp70 in MS pathogenesis, we examined its immune and cytoprotective roles using both in vitro and in vivo experimental procedures. We found that Hsp70. 1-deficient mice were more resistant to developing experimental autoimmune encephalomyelitis (EAE) compared with their wild-type (WT) littermates, suggesting that Hsp70. 1 plays a critical role in promoting an effective myelin oligodendrocyte glycoprotein (MOG)-specific T cell response. Conversely, Hsp70. 1-deficient mice that developed EAE showed an increased level of autoreactive T cells to achieve the same production of cytokines compared with the WT mice. Although a neuroprotective role of HSP70 has been suggested, Hsp70. 1-deficient mice that developed EAE did not exhibit increased demyelination compared with the control mice. Accordingly, Hsp70 deficiency did not influence the vulnerability to apoptosis of oligodendrocyte precursor cells (OPCs) in culture. Thus, the immunological role of Hsp70 may be relevant in EAE, and specific therapies down-regulating Hsp70 expression may be a promising approach to reduce the early autoimmune response in MS patients. |
| Grants: | Ministerio de Economía, Industria y Competitividad RD12/0032 Agència de Gestió d'Ajuts Universitaris i de Recerca 2009 SGR 0793 Ministerio de Sanidad y Consumo CP07/00146 Ministerio de Ciencia e Innovación D09/00363 |
| Rights: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.  |
| Language: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Published in: | PloS one, Vol. 9 (august 2014) , ISSN 1932-6203 |
