A Mitocentric View of the Main Bacterial and Parasitic Infectious Diseases in the Pediatric Population
Romero-Cordero, Sonia (Universitat Autònoma de Barcelona)
Kirwan, Richard (Liverpool John Moores University)
Noguera-Julian, Antoni (Universitat de Barcelona)
Cardellach, Francesc (Hospital Clínic i Provincial de Barcelona)
Fortuny Guasch, Claudia (Universitat de Barcelona)
Morén, Constanza (Hospital Clínic i Provincial de Barcelona)

Data:	2021
Resum:	Infectious diseases occur worldwide with great frequency in both adults and children. Both infections and their treatments trigger mitochondrial interactions at multiple levels: (i) incorporation of damaged or mutated proteins to the complexes of the electron transport chain, (ii) mitochondrial genome (depletion, deletions, and point mutations) and mitochondrial dynamics (fusion and fission), (iii) membrane potential, (iv) apoptotic regulation, (v) generation of reactive oxygen species, among others. Such alterations may result in serious adverse clinical events with great impact on children's quality of life, even resulting in death. As such, bacterial agents are frequently associated with loss of mitochondrial membrane potential and cytochrome c release, ultimately leading to mitochondrial apoptosis by activation of caspases-3 and -9. Using Rayyan QCRI software for systematic reviews, we explore the association between mitochondrial alterations and pediatric infections including (i) bacterial: M. tuberculosis, E. cloacae, P. mirabilis, E. coli, S. enterica, S. aureus, S. pneumoniae, N. meningitidis and (ii) parasitic: P. falciparum. We analyze how these pediatric infections and their treatments may lead to mitochondrial deterioration in this especially vulnerable population, with the intention of improving both the understanding of these diseases and their management in clinical practice.
Ajuts:	Instituto de Salud Carlos III PI17/00359 Ministerio de Economía, Industria y Competitividad PI13/01738 Generalitat de Catalunya PERIS2016-2020
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; Versió publicada
Publicat a:	International journal of molecular sciences, Vol. 22 (march 2021) , ISSN 1422-0067

DOI: 10.3390/ijms22063272
PMID: 33806981

41 p, 2.2 MB

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