A Mouse Model Suggests That Heart Failure and Its Common Comorbidity Sleep Fragmentation Have No Synergistic Impacts on the Gut Microbiome
Khannous-Lleiffe, Olfat (Institute for Research in Biomedicine (IRB Barcelona))
Willis, Jesse R. (Institute for Research in Biomedicine (IRB Barcelona))
Saus, Ester (Institute for Research in Biomedicine (IRB Barcelona))
Cabrera-Aguilera, Ignacio (Universitat de Barcelona)
Almendros, Isaac (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Farré, Ramon (Institut d'Investigacions Biomèdiques August Pi i Sunyer)
Gozal, David (The University of Missouri School of Medicine, Columbia, USA)
Farré, Núria (Universitat Autònoma de Barcelona. Departament de Medicina)
Gabaldón, Toni (Institució Catalana de Recerca i Estudis Avançats)

Fecha:	2021
Resumen:	Heart failure (HF) is a common condition associated with a high rate of hospitalizations and adverse outcomes. HF is characterized by impairments of either the cardiac ventricular filling, ejection of blood capacity or both. Sleep fragmentation (SF) involves a series of short sleep interruptions that lead to fatigue and contribute to cognitive impairments and dementia. Both conditions are known to be associated with increased inflammation and dysbiosis of the gut microbiota. In the present study, mice were distributed into four groups, and subjected for four weeks to either HF, SF, both HF and SF, or left unperturbed as controls. We used 16S metabarcoding to assess fecal microbiome composition before and after the experiments. Evidence for distinct alterations in several bacterial groups and an overall decrease in alpha diversity emerged in HF and SF treatment groups. Combined HF and SF conditions, however, showed no synergism, and observed changes were not always additive, suggesting preliminarily that some of the individual effects of either HF or SF cancel each other out when applied concomitantly.
Ayudas:	Agencia Estatal de Investigación SAF2017-85574-R Agencia Estatal de Investigación PGC2018-099921-B-I00
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Metagenomics ; Microbiome ; Sleep fragmentation ; Heart failure ; Sleep apnea
Publicado en:	Microorganisms, Vol. 9 (march 2021) , ISSN 2076-2607

DOI: 10.3390/microorganisms9030641
PMID: 33808770

16 p, 1.3 MB

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