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| Pàgina inicial > Articles > Articles publicats > Conservation of Aging and Cancer Epigenetic Signatures across Human and Mouse |
(Centro de Investigación Biomédica en Red de Enfermedades Raras) (Centro de Investigación Biomédica en Red de Enfermedades Raras) (Centro de Investigación Biomédica en Red de Enfermedades Raras) (Centro de Investigación Biomédica en Red de Enfermedades Raras) (Universitat Autònoma de Barcelona. Departament de Bioquímica i de Biologia Molecular) (Institució Catalana de Recerca i Estudis Avançats) (Centro de Investigación Biomédica en Red de Enfermedades Raras) (Centro de Investigación Biomédica en Red de Enfermedades Raras)
| Data: | 2021 |
| Resum: | Aging and cancer are two interrelated processes, with aging being a major risk factor for the development of cancer. Parallel epigenetic alterations have been described for both, although differences, especially within the DNA hypomethylation scenario, have also been recently reported. Although many of these observations arise from the use of mouse models, there is a lack of systematic comparisons of human and mouse epigenetic patterns in the context of disease. However, such comparisons are significant as they allow to establish the extent to which some of the observed similarities or differences arise from pre-existing species-specific epigenetic traits. Here, we have used reduced representation bisulfite sequencing to profile the brain methylomes of young and old, tumoral and nontumoral brain samples from human and mouse. We first characterized the baseline epigenomic patterns of the species and subsequently focused on the DNA methylation alterations associated with cancer and aging. Next, we described the functional genomic and epigenomic context associated with the alterations, and finally, we integrated our data to study interspecies DNA methylation levels at orthologous CpG sites. Globally, we found considerable differences between the characteristics of DNA methylation alterations in cancer and aging in both species. Moreover, we describe robust evidence for the conservation of the specific cancer and aging epigenomic signatures in human and mouse. Our observations point toward the preservation of the functional consequences of these alterations at multiple levels of genomic regulation. Finally, our analyses reveal a role for the genomic context in explaining disease- and species-specific epigenetic traits. |
| Ajuts: | Ministerio de Economía y Competitividad PI15/00892 Instituto de Salud Carlos III PI18/01527 Agencia Estatal de Investigación SAF2017-85766-R Agencia Estatal de Investigación RYC-2017-22335 European Commission 777222 Ministerio de Economía y Competitividad FJCI-2015-26965 |
| Drets: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.  |
| Llengua: | Anglès |
| Document: | Article ; recerca ; Versió publicada |
| Matèria: | Epigenetics ; DNA methylation ; Histone modification ; Mouse ; Human ; Conservation |
| Publicat a: | Molecular biology and evolution, Vol. 38, Issue 8 (August 2021) , p. 3415-3435, ISSN 1537-1719 |
