Sodium Butyrate More Effectively Mitigates the Negative Effects of High-Concentrate Diet in Dairy Cows than Sodium β -Hydroxybutyrate via Reducing Free Bacterial Cell Wall Components in Rumen Fluid and Plasma
Wu, Yongjiang (Southwest University. College of Animal Science and Technology)
Sun, Yawang (Southwest University. College of Animal Science and Technology)
Zhang, Ruiming (Southwest University. College of Animal Science and Technology)
He, Tianle (Southwest University. College of Animal Science and Technology)
Huang, Guohao (Southwest University. College of Animal Science and Technology)
Tian, Ke (Gifu University. United Graduate School of Agricultural Science)
Liu, Junhui (Centre de Recerca en Agrigenòmica)
Chen, Juncai (Southwest University. College of Animal Science and Technology)
Dong, Guozhong (Southwest University. College of Animal Science and Technology)

Date:	2021
Abstract:	The present study was aimed at investigating the effects of sodium butyrate and sodium β -hydroxybutyrate on lactation and health of dairy cows fed a high-concentrate (HC) diet. Eighty mid-lactation dairy cows with an average milk yield of 33. 75 ± 5. 22 kg/d were randomly allocated to four groups (n = 20 per group) and were fed either a low-concentrate (LC) diet, a HC diet, the HC diet with 1% sodium butyrate (HCSB), or the HC diet with 1% sodium β -hydroxybutyrate (HCHB). The feeding trial lasted for 7 weeks, with a 2-week adaptation period and a 5-week measurement period, and the trial started from 96 ± 13 d in milk. Sodium butyrate supplementation delayed the decline in milk production and improved milk synthesis efficiency and milk fat content. Additionally, it decreased the proinflammatory cytokines and acute phase proteins (APPs) in plasma, the leucocytes in blood, the somatic cell count (SCC) in milk, and the gene expression of pattern recognition receptors (PRRs) and proinflammatory cytokines in the mammary gland, due to decreasing the contents of bacterial cell wall components (lipopolysaccharide, LPS; peptidoglycan, PGN; and lipoteichoic acid, LTA) in the rumen and plasma, compared with the HC diet. Sodium β -hydroxybutyrate supplementation also improved milk yield, milk synthesis efficiency and milk fat content and partially reduced the adverse effects caused by the HC diet, but it had no effect on decreasing bacterial cell wall components in the rumen and plasma, compared with the HC diet. Collectively, both sodium butyrate and sodium β -hydroxybutyrate mitigated the negative effects of HC diet on lactation and health of dairy cows, with sodium butyrate being more effective than sodium β -hydroxybutyrate.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Sodium butyrate ; Sodium β -hydroxybutyrate ; Lipopolysaccharide ; Peptidoglycan ; Lipoteichoic acid ; Dairy cows
Published in:	Toxins, Vol. 13, Issue 5 (May 2021) , art. 352, ISSN 2072-6651

DOI: 10.3390/toxins13050352
PMID: 34069117

16 p, 1.7 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > CRAG (Centre for Research in Agricultural Genomics)
Articles > Research articles
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