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Página principal > Artículos > Artículos publicados > Usefulness of Cardiac Computed Tomography in Coronary Risk Prediction : |
Fecha: | 2022 |
Resumen: | Accurate identification of individuals at high coronary risk would reduce acute coronary syndrome incidence and morbi-mortality. We analyzed the effect on coronary risk prediction of adding coronary artery calcification (CAC) and Segment Involvement Score (SIS) to cardiovascular risk factors. This was a prospective cohort study of asymptomatic patients recruited between 2013-2017. All participants underwent a coronary computed tomography angiography to determine CAC and SIS. The cohort was followed-up for a composite endpoint of myocardial infarction, coronary angiography and/or revascularization (median = five years). Discrimination and reclassification of the REGICOR function with CAC/SIS were examined with the Sommer's D index and with the Net reclassification index (NRI). Nine of the 251 individuals included had an event. Of the included participants, 94 had a CAC = 0 and 85 a SIS = 0, none of them had an event. The addition of SIS or of SIS and CAC to the REGICOR risk function significantly increased the discrimination capacity from 0. 74 to 0. 89. Reclassification improved significantly when SIS or both scores were included. CAC and SIS were associated with five-year coronary event incidence, independently of cardiovascular risk factors. Discrimination and reclassification of the REGICOR risk function were significantly improved by both indexes, but SIS overrode the effect of CAC. |
Ayudas: | Instituto de Salud Carlos III CB16/11/00229 Instituto de Salud Carlos III CB16/11/00276 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017/SGR-222 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Coronary artery disease risk ; Cardiac computed tomography ; Coronary artery calcium ; Primary prevention |
Publicado en: | Journal of clinical medicine, Vol. 11 (january 2022) , ISSN 2077-0383 |
9 p, 461.7 KB |