Outcomes of Frail Patients While Waiting for Kidney Transplantation : Differences between Physical Frailty Phenotype and FRAIL Scale
Pérez-Sáez, María José (Hospital del Mar (Barcelona, Catalunya))
Redondo-Pachón, Dolores (Hospital del Mar (Barcelona, Catalunya))
Arias Cabrales, Carlos E (Hospital del Mar (Barcelona, Catalunya))
Faura, Anna (Hospital del Mar (Barcelona, Catalunya))
Bach Pascual, Anna (Hospital del Mar (Barcelona, Catalunya))
Buxeda, Anna (Hospital del Mar (Barcelona, Catalunya))
Burballa, Carla (Hospital del Mar (Barcelona, Catalunya))
Junyent, Ernestina (Hospital del Mar (Barcelona, Catalunya))
Crespo, Marta (Hospital del Mar (Barcelona, Catalunya))
Marco, Ester (Institut Hospital del Mar d'Investigacions Mèdiques)
Rodríguez-Mañas, Leocadio (Hospital Universitario de Getafe (Madrid))
Pascual Santos, Julio (Hospital del Mar (Barcelona, Catalunya))

Date:	2022
Abstract:	Frailty is associated with poorer outcomes among patients waiting for kidney transplantation (KT). Several different tools to measure frailty have been used; however, their predictive value is unknown. This is a prospective longitudinal study of 449 KT candidates evaluated for frailty by the Physical Frailty Phenotype (PFP) and the FRAIL scale. During the study period, 296 patients received a KT, while 153 remained listed. Patients who did not get receive a transplant were more frequently frail according to PFP (16. 3 vs. 7. 4%, p = 0. 013). Robust patients had fewer hospital admissions during the 1st year after listing (20. 8% if PFP = 0 vs. 43. 4% if ≥1, and 27. 1% if FRAIL = 0 vs. 48. 9% if ≥1) and fewer cardiovascular events (than FRAIL ≥ 1) or major infectious events (than PFP ≥ 1). According to PFP, scoring 1 point had an impact on patient survival and chance of transplantation in the univariate analysis. The multivariable analysis corroborated the result, as candidates with PFP ≥ 3 had less likelihood of transplantation (HR 0. 45 [0. 26-0. 77]). The FRAIL scale did not associate with any of these outcomes. In KT candidates, pre-frailty and frailty according to both the PFP and the FRAIL scale were associated with poorer results while listed. The PFP detected that frail patients were less likely to receive a KT, while the FRAIL scale did not.
Grants:	Instituto de Salud Carlos III PI19/00037
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Frailty ; FRAIL ; Kidney transplant waiting list
Published in:	Journal of clinical medicine, Vol. 11 (january 2022) , ISSN 2077-0383

DOI: 10.3390/jcm11030672
PMID: 35160125

15 p, 1.7 MB

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