Immune Dysregulation and the Increased Risk of Complications and Mortality Following Respiratory Tract Infections in Adults With Down Syndrome
Illouz, Tomer (Bar-Ilan University)
Biragyn, Arya (National Institute on Aging, National Institute of Health, Baltimore)
Iulita, M. Florencia (Institut d'Investigació Biomèdica Sant Pau)
Flores-Aguilar, Lisi (McGill University)
Dierssen, Mara (Centro de Investigación Biomédica en Red de Enfermedades Raras)
De Toma, Ilario (Centro de Investigación Biomédica en Red de Enfermedades Raras)
Antonarakis, Stylianos E. (iGE3 Institute of Genetics and Genomics of Geneva)
Yu, Eugene (State University of New York at Buffalo)
Herault, Yann (Université de Strasbourg)
Potier, Marie-Claude (Paris Brain Institute (ICM))
Botté, Alexandra (Paris Brain Institute (ICM))
Roper, Randall (Indiana University-Purdue University Indianapolis)
Sredni, Benjamin (Bar-Ilan University)
London, Jacqueline (Université de Paris)
Mobley, William (University of California, San Diego)
Strydom, Andre (South London and Maudsley NHS Foundation Trust)
Okun, Eitan (Bar-Ilan University)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	The risk of severe outcomes following respiratory tract infections is significantly increased in individuals over 60 years, especially in those with chronic medical conditions, i. e. , hypertension, diabetes, cardiovascular disease, dementia, chronic respiratory disease, and cancer. Down Syndrome (DS), the most prevalent intellectual disability, is caused by trisomy-21 in ~1:750 live births worldwide. Over the past few decades, a substantial body of evidence has accumulated, pointing at the occurrence of alterations, impairments, and subsequently dysfunction of the various components of the immune system in individuals with DS. This associates with increased vulnerability to respiratory tract infections in this population, such as the influenza virus, respiratory syncytial virus, SARS-CoV-2 (COVID-19), and bacterial pneumonias. To emphasize this link, here we comprehensively review the immunobiology of DS and its contribution to higher susceptibility to severe illness and mortality from respiratory tract infections.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Down syndrome ; Immune dysregulation ; Hospitalization ; Respiratory tract infections ; Interferon ; COVID-19
Publicado en:	Frontiers in immunology, Vol. 12 (june 2021) , ISSN 1664-3224

DOI: 10.3389/fimmu.2021.621440
PMID: 34248930

20 p, 1.6 MB

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