Cortical metabolic and structural differences in patients with chronic migraine. An exploratory 18 FDG-PET and MRI study
Torres-Ferrús, Marta (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Pareto, Deborah (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Gallardo, Víctor J.. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Cuberas-Borrós, Gemma (Hospital Universitari Vall d'Hebron)
Alpuente, Alicia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Caronna, Edoardo (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Vila-Balló, Adrià (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lorenzo-Bosquet, Carles (Hospital Universitari Vall d'Hebron)
Castell-Conesa, Joan (Hospital Universitari Vall d'Hebron)
Rovira, Alex (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Pozo-Rosich, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Fecha:	2021
Resumen:	To describe interictal brain structural and metabolic differences between patients with episodic migraine (EM), chronic migraine (CM) and healthy controls (HC). This is an exploratory study including right-handed age-matched women with EM, CM and HC. On the same day, a sequential interictal scan was performed with 18 FDG-PET and MRI. 3D T1-weighted images were segmented with FreeSurfer, normalized to a reference atlas and the mean values of metabolism, cortical thickness (CTh) and local gyrification index (IGI) were determined. Groups were compared using age-adjusted linear models, corrected for multiple comparisons. 18 FDG-PET measurements between groups were also analysed adjusting by patient's age, CTh and lGI. The variables independently associated with diagnosis were obtained using a logistic regression analysis. Fifteen patients (8 EM, 7 CM) and 11 HC were included. Morphometric data showed an increased CTh in 6 frontal areas (L/R-Caudal Middle Frontal, L/R-Rostral Middle Frontal, L-Medial Orbitofrontal and L-Superior Frontal) in CM patients compared to HC without differences for IGI. The structural adjusted analysis in CM showed a statistically significantly hypometabolism in 9 frontal areas (L-Lateral Orbitofrontal, L/R-Medial Orbitofrontal, L-Frontal Superior, R-Frontal pole, R-Parts Triangularis, L/R-Paracentral and R-Precentral) and 7 temporal areas (L/R-Insula, L/R-Inferior temporal, L/R-Temporal pole and R-Banks superior temporal sulcus) compared to HC. EM patients presented intermediate metabolic values ​​between EM and HC (non-significant). CM patients showed frontotemporal hypometabolism and increased frontal cortical thickness when compared to HC that may explain some cognitive and behavioural pain-processing and sensory integration alterations in CM patients. Combined information from sequential or simultaneous PET and MRI could optimize the study of complex functional neurological disorders such as migraine. The online version contains supplementary material available at 10. 1186/s10194-021-01289-5.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Chronic migraine ; Neuroimaging ; Positron emission tomography ; Cortical thickness ; Metabolism ; Structural
Publicado en:	Journal of headache and pain, Vol. 22 (july 2021) , ISSN 1129-2377

DOI: 10.1186/s10194-021-01289-5
PMID: 34273945

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