Hormone Targets for the Treatment of Sleep Disorders in Postmenopausal Women with Schizophrenia : A Narrative Review
González-Rodríguez, Alexandre (Universitat de Barcelona)
Haba-Rubio, José (Centre Hospitalier Universitaire Vaudois (Suïssa))
Usall, Judith (Parc Sanitari Sant Joan de Déu)
Natividad, Mentxu (Universitat de Barcelona)
Soria, Virginia (Institut d'Investigació Biomèdica de Bellvitge)
Labad, Javier (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Monreal, José Antonio (Universitat Autònoma de Barcelona. Institut de Neurociències)

Date:	2022
Abstract:	While the early identification of insomnia in patients with schizophrenia is of clinical relevance, the use of specific compounds to treat insomnia has been studied less in postmenopausal women with schizophrenia. We aimed to explore the effects of melatonin, sex hormones, and raloxifene for the treatment of insomnia in these populations. Although melatonin treatment improved the quality and efficiency of the sleep of patients with schizophrenia, few studies have explored its use in postmenopausal women with schizophrenia. The estrogen and progesterone pathways are dysregulated in major psychiatric disorders, such as in schizophrenia. While, in the context of menopause, a high testosterone-to-estradiol ratio is associated with higher frequencies of depressive symptoms, the effects of estradiol and other sex hormones on sleep disorders in postmenopausal women with schizophrenia has not been sufficiently investigated. Raloxifene, a selective estrogen receptor modulator, has shown positive effects on sleep disorders in postmenopausal women. Future studies should investigate the effectiveness of hormonal compounds on insomnia in postmenopausal women with schizophrenia.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Schizophrenia ; Delusional disorder ; Sleep ; Insomnia ; Treatment
Published in:	Clocks & Sleep, Vol. 4 (february 2022) , p. 52-65, ISSN 2624-5175

DOI: 10.3390/clockssleep4010007
PMID: 35225953

14 p, 472.4 KB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles