Innate but not adaptive immunity regulates lung recovery from chronic exposure to graphene oxide nanosheets
Loret, Thomas (Manchester Academic Health Science Centre)
De Luna, Luis Augusto Visani (Manchester Academic Health Science Centre)
Fordham, Alexander (Manchester Academic Health Science Centre)
Arshad, Atta (The University of Manchester. Nanomedicine Lab)
Barr, Katharine (The University of Manchester. Nanomedicine Lab)
Lozano, Neus (Institut Català de Nanociència i Nanotecnologia)
Kostarelos, Kostas (Institut Català de Nanociència i Nanotecnologia)
Bussy, Cyrill (Manchester Academic Health Science Centre)

Data:	2022
Resum:	Graphene has drawn a lot of interest in the material community due to unique physicochemical properties. Owing to a high surface area to volume ratio and free oxygen groups, the oxidized derivative, graphene oxide (GO) has promising potential as a drug delivery system. Here, the lung tolerability of two distinct GO varying in lateral dimensions is investigated, to reveal the most suitable candidate platform for pulmonary drug delivery. Following repeated chronic pulmonary exposure of mice to GO sheet suspensions, the innate and adaptive immune responses are studied. An acute and transient influx of neutrophils and eosinophils in the alveolar space, together with the replacement of alveolar macrophages by interstitial ones and a significant activation toward anti-inflammatory subsets, are found for both GO materials. Micrometric GO give rise to persistent multinucleated macrophages and granulomas. However, neither adaptive immune response nor lung tissue remodeling are induced after exposure to micrometric GO. Concurrently, milder effects and faster tissue recovery, both associated to a faster clearance from the respiratory tract, are found for nanometric GO, suggesting a greater lung tolerability. Taken together, these results highlight the importance of dimensions in the design of biocompatible 2D materials for pulmonary drug delivery system.
Ajuts:	European Commission 881603 Agencia Estatal de Investigación SEV-2017-0706
Nota:	Altres ajuts: the ICN2 is funded by the CERCA programme, Generalitat de Catalunya.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Adaptive immunity ; Chronic exposure ; Graphene oxide ; Innate immunity ; Lungs ; Nanomaterials
Publicat a:	Advanced science, Vol. 9, issue 11 (April 2022) , ISSN 2198-3844

DOI: 10.1002/advs.202104559
PMID: 35166457

16 p, 4.4 MB

El registre apareix a les col·leccions:
Documents de recerca > Documents dels grups de recerca de la UAB > Centres i grups de recerca (producció científica) > Ciències > Institut Català de Nanociència i Nanotecnologia (ICN2)
Articles > Articles de recerca
Articles > Articles publicats