Effect of colonic distension on small bowel motility measured by jejunal high-resolution manometry
Alcalá González, Luis Gerardo (Universitat Autònoma de Barcelona. Departament de Medicina)
Malagelada Prats, Carolina (Universitat Autònoma de Barcelona. Departament de Medicina)
Livovsky, Dan M. (Universitat Autònoma de Barcelona. Departament de Medicina)
Azpiroz Vidaur, Fernando (Hospital Universitari Vall d'Hebron)

Date:	2022
Abstract:	Background: Abnormal motility patterns in the jejunum can be detected in patients with prominent colonic content, and these abnormalities may be due to either a primary jejunal dysfunction or a reflex distortion. The objective of the present study was to determine the effect of colonic distension on small bowel postprandial motility using high-resolution manometry. Methods: Single center, controlled, parallel, randomized, single blind study in healthy subjects testing the effect of colonic filling vs sham infusion on the responses to a meal in 16 healthy subjects. Nutrients were continuously infused in the proximal jejunum (2 Kcal/min) during the 2-h study period to induce a steady-state postprandial motor pattern. Jejunal motility was measured by water-perfused, high-resolution manometry. After 1 h postprandial recording (basal period), gas was infused during 7. 5 min via a rectal tube (720 mL or sham infusion), and jejunal motility was recorded for another hour. Key Results: Jejunal postprandial motility during the basal period was characterized by two overlapping components: a) continuous segmental activity (non-propagated or shortly propagated) and b) intercurrent propagated fronts (3. 8 ± 1. 1 fronts of 2-5 clustered contractions/h.
Grants:	Instituto de Salud Carlos III CM20/00182 Instituto de Salud Carlos III PI17/01794 Agencia Estatal de Investigación SAF2016-76648-R
Note:	Altres ajuts: acords transformatius de la UAB
Note:	Altres ajuts: Israeli Gastroenterological Association; Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; Societat Catalana de Digestologia
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Colonic distension ; High-resolution manometry ; Postprandial motility ; Propagated contractions ; Small bowel motility
Published in:	Neurogastroenterology & motility, 2022 , ISSN 1365-2982

DOI: 10.1111/nmo.14351
PMID: 35318777

8 p, 1.2 MB

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