The Microbiome Meets Nanotechnology : Opportunities and Challenges in Developing New Diagnostic Devices
Fuentes-Chust, Celia (Institut Català de Nanociència i Nanotecnologia)
Parolo, Claudio (Institut Català de Nanociència i Nanotecnologia)
Rosati, Giulio (Institut Català de Nanociència i Nanotecnologia)
Rivas, Lourdes (Institut Català de Nanociència i Nanotecnologia)
Perez-Toralla, Karla (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé)
Simon, Stéphanie (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé)
Lecuona, Itziar de (Universitat de Barcelona. Departament de Medicina)
Junot, Christophe (Université Paris-Saclay. Département Médicaments et Technologies pour la Santé)
Trebicka, Jonel (University Frankfurt. Department of Internal Medicine I)
Merkoçi, Arben (Institut Català de Nanociència i Nanotecnologia)

Date:	2021
Abstract:	Monitoring of the human microbiome is an emerging area of diagnostics for personalized medicine. Here, the potential of different nanomaterials and nanobiosensing technologies is reviewed for the development of novel diagnostic devices for the detection and measurement of microbiome-related biomarkers. Moreover, the current and future landscape of microbiome-based diagnostics is defined by exploring the advantages and disadvantages of current nanotechnology-based approaches, especially in the context of developing point-of-care (PoC) devices that would meet the international guidelines known as REASSURED (Real-time connectivity; Ease of specimen collection; Affordability; Sensitivity; Specificity; User-friendliness; Rapid & robust operation; Equipment-free; and Deliverability). Finally, the strategies of the latest international scientific consortia working in this field are analyzed, the current microbiome diagnostics market are reported and the principal ethical, legal, and societal issues related to microbiome R&D and innovation are discussed.
Grants:	European Commission 825694 European Commission 795635
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Advanced materials, Vol. 33, Issue 18 (May 2021) , art. 2006104, ISSN 1521-4095

DOI: 10.1002/adma.202006104

18 p, 5.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles