Neural Substrates of Psychotic Depression : Findings From the Global ECT-MRI Research Collaboration
Takamiya, Akihiro (Leuven Brain Institute. Department of Neurosciences and Neuropsychiatry)
Dols, Annemiek (Vrije Universiteit Amsterdam. Department of Psychiatry)
Emsell, Louise (Leuven Brain Institute. Department of Neurosciences and Neuropsychiatry)
Abbott, Christopher (University of New Mexico. Department of Psychiatry)
Yrondi, Antoine (Hospital Purpan. Service de Psychiatrie et de Psychologie Médicale (Toulouse))
Soriano-Mas, Carles (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Jorgensen, Martin Balslev (University of Copenhagen. Institute of Clinical Medicine)
Nordanskog, Pia (Linköping University. Department of Clinical and Experimental Medicine)
Rhebergen, Didi (Mental Health Care Institute, GGZ Centraal)
van Exel, Eric (Vrije Universiteit Amsterdam. Department of Psychiatry)
Oudega, Mardien L. (Vrije Universiteit Amsterdam. Department of Psychiatry)
Bouckaert, Filip (Leuven Brain Institute. Department of Neurosciences and Neuropsychiatry)
Vandenbulcke, Mathieu (Leuven Brain Institute. Department of Neurosciences and Neuropsychiatry)
Sienaert, Pascal (Katholieke Universiteit Leuven. University Psychiatric Center)
Péran, Patrice (Toulouse NeuroImaging Center)
Cano, Marta (Universitat Autònoma de Barcelona. Departament de Psicobiologia i de Metodologia de Ciències de la Salut)
Cardoner, N. (Narcís) (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Jorgensen, Anders (University of Copenhagen. Institute of Clinical Medicine)
Paulson, Olaf B. (Copenhagen University Hospital Rigshospitalet)
Hamilton, Paul (Linköping University. Department of Biomedical and Clinical Sciences)
Kampe, Robin (Linköping University. Department of Biomedical and Clinical Sciences)
Bruin, Willem Benjamin (Amsterdam Neuroscience. Department of Psychiatry)
Bartsch, Hauke (University of Bergen. Department of Informatics)
Ousdal, Olga Therese (University of Bergen. Centre for Crisis Psychology)
Kessler, Ute (Haukeland University Hospital (Bergen, Noruega))
van Wingen, Guido (Amsterdam Neuroscience. Department of Psychiatry)
Oltedal, Leif (University of Bergen. Department of Clinical Medicine)
Kishimoto, Taishiro (Keio University School of Medicine. Department of Neuropsychiatry)
Université de Toulouse
Linköping University. Center for Social and Affective Neuroscience (CSAN)

Date:	2022
Abstract:	Psychotic major depression (PMD) is hypothesized to be a distinct clinical entity from nonpsychotic major depression (NPMD). However, neurobiological evidence supporting this notion is scarce. The aim of this study is to identify gray matter volume (GMV) differences between PMD and NPMD and their longitudinal change following electroconvulsive therapy (ECT). Structural magnetic resonance imaging (MRI) data from 8 independent sites in the Global ECT-MRI Research Collaboration (GEMRIC) database (n = 108; 56 PMD and 52 NPMD; mean age 71. 7 in PMD and 70. 2 in NPMD) were analyzed. All participants underwent MRI before and after ECT. First, cross-sectional whole-brain voxel-wise GMV comparisons between PMD and NPMD were conducted at both time points. Second, in a flexible factorial model, a main effect of time and a group-by-time interaction were examined to identify longitudinal effects of ECT on GMV and longitudinal differential effects of ECT between PMD and NPMD, respectively. Compared with NPMD, PMD showed lower GMV in the prefrontal, temporal and parietal cortex before ECT; PMD showed lower GMV in the medial prefrontal cortex (MPFC) after ECT. Although there was a significant main effect of time on GMV in several brain regions in both PMD and NPMD, there was no significant group-by-time interaction. Lower GMV in the MPFC was consistently identified in PMD, suggesting this may be a trait-like neural substrate of PMD. Longitudinal effect of ECT on GMV may not explain superior ECT response in PMD, and further investigation is needed.
Grants:	Instituto de Salud Carlos III CD20/00189
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Psychosis ; Depression ; Magnetic resonance imaging ; Gray matter volume ; Medial prefrontal cortex
Published in:	Schizophrenia bulletin, Vol. 48 num 2 (march 2022) , p. 514-523, ISSN 1745-1701

DOI: 10.1093/schbul/sbab122
PMID: 34624103

10 p, 21.7 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles