Swine as the Animal Model for Testing New Formulations of Anti-Inflammatory Drugs : Carprofen Pharmacokinetics and Bioavailability of the Intramuscular Route
Gómez-Segura, Lídia (Universitat Autònoma de Barcelona. Departament de Medicina i Cirurgia Animals)
Boix-Montañes, Antonio (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia)
Mallandrich, Mireia (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia)
Parra Coca, Alexander (University of Applied and Environmental Sciences. Department of Veterinary Medicine and Zootechnic)
Soriano-Ruiz, José L. (Universidad de Granada. Departamento de Farmacia)
Calpena-Campmany, Ana Cristina (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia)
Gimeno, Álvaro (Universitat de Barcelona. Departament de Recerca Animal)
Bellido, David (Universitat de Barcelona. Centres Científics i Tecnològics)
Colom, Helena (Universitat de Barcelona. Institut de Nanociència i Nanotecnologia)

Data:	2022
Resum:	Carprofen (CP) is a non-steroidal anti-inflammatory drug (NSAID) frequently used to treat respiratory diseases in numerous small animals, but also in large species. CP is a formidable candidate for further therapeutic research of human inflammatory diseases using the pig as an animal model. However, CP administration in swine is very uncommon and respective pharmacokinetics/bioavailability studies are scarce. A simultaneous population pharmacokinetic analysis after CP intravenous and intramuscular administrations in pigs has shown high extent and rate of absorption and a similar distribution profile with respect to man and other mammals. However, clearance and half-life values found in swine suggest a slower elimination process than that observed in man and some other animal species. Although not reported in other species, liver and kidney concentrations achieved at 48 h post-intramuscular administration in pigs were ten times lower than those found in plasma. Simulations pointed to 4 mg/kg every 24 h as the best dosage regimen to achieve similar therapeutic levels to those observed in other animal species. All these findings support the use of pig as an animal model to study the anti-inflammatory effects of CP in humans.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Population pharmacokinetics ; Tissue distribution ; Swine animal model ; Mass spectrometry ; Bioanalysis ; Carprofen ; Anti-inflammatory drugs
Publicat a:	Pharmaceutics, Vol. 14 (may 2022) , ISSN 1999-4923

DOI: 10.3390/pharmaceutics14051045
PMID: 35631631

16 p, 1.9 MB

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