Clinicopathological features, MCPyV status and outcomes of Merkel cell carcinoma in solid-organ transplant recipients : a retrospective, multicentre cohort study
Ferrandiz-Pulido, Carla (Universitat Autònoma de Barcelona. Departament de Medicina)
Gómez-Tomás, A. (Hospital Universitari Vall d'Hebron)
Llombart, B. (Fundació Institut Valencià d'Oncologia)
Mendoza, D. (Hospital Universitario Fundación Jiménez Díaz)
Marcoval, Joaquim (Hospital Universitari de Bellvitge)
Piaserico, S. (Università di Padova. Department of Medicine)
Baykal, C. (Department of Dermatology. Istanbul University)
Bouwes-Bavinck, J. N. (Department of Dermatology. Leiden University Medical Center)
Rácz, E. (Department of Dermatology. University of Groningen)
Kanitakis, J. (Department of Dermatology. Edouard Herriot Hospital Group. Hospices Civils de Lyon)
Harwood, C. A. (Centre for Cell Biology and Cutaneous Research. Blizard Institute. Barts and The London School of Medicine and Dentistry. Queen Mary University of London)
Cetkovská, P. (Department of Dermatovenereology. Faculty of Medicine. Charles University)
Geusau, Alexandra (Medical University of Vienna)
del Marmol, V. (Service de Dermatologie. Hôpital Erasme. Université Libre de Bruxelles)
Masferrer, Emili (Hospital Universitari MútuaTerrassa (Terrassa, Catalunya))
Orte Cano, C. (Service de Dermatologie. Hôpital Erasme. Université Libre de Bruxelles)
Ricar, J. (Department of Dermatovenereology. Faculty of Medicine. Charles University)
de Oliveira, W. R. (Department of Dermatology. University of São Paulo)
Salido-Vallejo, R. (Clínica Universidad de Navarra)
Ducroux, E. (Department of Dermatology. Edouard Herriot Hospital Group. Hospices Civils de Lyon)
Gkini, M. A. (Centre for Cell Biology and Cutaneous Research. Blizard Institute. Barts and The London School of Medicine and Dentistry. Queen Mary University of London)
López-Guerrero, J. A. (Department of Pathology. School of Medicine. Catholic University of Valencia 'San Vicente Martir')
Kutzner, H. (Dermatopathologie)
Kempf, W. (Kempf und Pfaltz Histologische Diagnostik and Department of Dermatology. University Hospital Zurich)
Seçkin, D. (Department of Dermatology. Başkent University Faculty of Medicine)

Data:	2022
Resum:	Background: The proportion of Merkel cell carcinomas (MCCs) in solid-organ transplant recipients (SOTR) harbouring Merkel cell polyomavirus (MCPyV) is unknown, as are factors affecting their outcomes. Objective: To describe clinicopathological features of MCC in SOTR, investigate the tumoral MCPyV-status and identify factors associated with tumour outcomes. Methods: Retrospective, international, cohort-study. MCPyV-status was investigated by immunohistochemistry and polymerase chain reaction. Results: A total of 30 SOTR and 44 consecutive immunocompetent patients with MCC were enrolled. SOTR were younger at diagnosis (69 vs. 78 years, P < 0. 001). Thirty-three percent of SOTR MCCs were MCPyV-positive vs. 91% of immunocompetent MCCs (P = 0. 001). Solid-organ transplantation was associated with an increased cumulative incidence of progression (SHR: 3. 35 [1. 57-7. 14], P = 0. 002), MCC-specific mortality (SHR: 2. 55 [1. 07-6. 06], P = 0. 034) and overall mortality (HR: 3. 26 [1. 54-6. 9], P = 0. 002). MCPyV-positivity and switching to an mTOR inhibitor (mTORi) after MCC diagnosis were associated with an increased incidence of progression (SHR: 4. 3 [1. 5-13], P = 0. 008 and SHR: 3. 6 [1. 1-12], P = 0. 032 respectively) in SOTR. Limitations: Retrospective design and heterogeneity of SOTR cohort. Conclusions: MCPyV appears to play a less prominent role in the aetiopathogenesis of MCC in SOTR. SOTR have a worse prognosis than their immunocompetent counterparts and switching to an mTORi after the diagnosis of MCC does not improve progression.
Nota:	Altres ajuts: acords transformatius de la UAB
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Publicat a:	Journal of the European Academy of Dermatology and Venereology, 2022 , ISSN 1468-3083

DOI: 10.1111/jdv.18256
PMID: 35607918

11 p, 746.9 KB

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