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Página principal > Artículos > Artículos publicados > Prevalence and Predictors of Cerebral Microangiopathy Determined by Pulsatility Index in an Asymptomatic Population From the ILERVAS Project |
Fecha: | 2021 |
Resumen: | Background: Little is known about the prevalence of cerebral microangiopathy (CM), which is related to cognitive impairment, in an asymptomatic population. Pulsatility index (PI) is an easily measurable parameter of cerebral vascular resistance in transcranial duplex of the middle cerebral artery (MCA) study. We aimed to determine the prevalence of CM measured by PI of MCA in low to moderate vascular risk subjects. Methods: We included 3,721 subjects between 45 and 70 years without previous history of vascular disease or diabetes mellitus and with at least one other vascular risk factor from the cross-sectional study ILERVAS (Lleida, Spain). Patients underwent transcranial duplex to determine MCA-PI. Possible CM was defined by MCA-PI >1. 1. Carotid and femoral arteries ultrasound registration was done to determine the presence, the number, and the area of atheromatous plaques. Body mass index (BMI), pulse pressure (PP) and laboratory data were also recorded. Results: 439 (11. 8%) subjects were excluded due to the low quality of transcranial duplex images. Median age was 57 [IQR 52, 62] years. Possible CM was found in 424 (12. 9%) subjects. CM patients had higher prevalence of plaques than non-CM (77. 4 vs. 66. 4%, p < 0. 001). PI showed a positive linear correlation with the number of territories with plaques (r = 0. 130, p < 0. 001), and the total plaque area (r = 0. 082, p < 0. 001). The predictors of possible CM were the age, male gender, and PP. Conclusions: In low-to-moderate vascular risk asymptomatic population, the proportion of abnormal brain microvascular bed determined by MCA-PI is not negligible. The planned 10-year follow-up will describe the clinical relevance of these findings. |
Ayudas: | Ministerio de Ciencia e Innovación IJC2018-037792-I Ministerio de Ciencia e Innovación RTI2018-099200-B-I00 Instituto de Salud Carlos III RETIC RD16/0009/0011 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017-SGR-696 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Atheromatosis ; Cerebral microangiopathy ; Extracranial atheromatosis ; Pulsatility index (PI) ; Transcranial Doppler (TCD) ; Ultrasonography |
Publicado en: | Frontiers in neurology, Vol. 12 (14 2021) , p. 785640, ISSN 1664-2295 |
7 p, 360.5 KB |