Postnatal environmental enrichment enhances memory through distinct neural mechanisms in healthy and trisomic female mice
Alemany-González, Maria (Institut Hospital del Mar d'Investigacions Mèdiques)
Vilademunt, Marta (Institut Hospital del Mar d'Investigacions Mèdiques)
Gener, Thomas (Institut Català de Nanociència i Nanotecnologia)
Puig, Maria Victoria (Institut Català de Nanociència i Nanotecnologia)

Date:	2022
Abstract:	Stimulating lifestyles have powerful effects on cognitive abilities, especially when they are experienced early in life. Cognitive therapies are widely used to improve cognitive impairment due to intellectual disability, aging, and neurodegeneration, however the underlying neural mechanisms are poorly understood. We investigated the neural correlates of memory amelioration produced by postnatal environmental enrichment (EE) in diploid mice and the Ts65Dn mouse model of Down syndrome (trisomy 21). We recorded neural activities in brain structures key for memory processing, the hippocampus and the prefrontal cortex, during rest, sleep and memory performance in mice reared in non-enriched or enriched environments. Enriched wild-type animals exhibited enhanced neural synchrony in the hippocampus across different brain states (increased gamma oscillations, theta-gamma coupling, sleep ripples). Trisomic females showed increased theta and gamma rhythms in the hippocampus and prefrontal cortex across different brain states along with enlarged ripples and disrupted circuit gamma signals that were associated with memory deficits. These pathological activities were attenuated in their trisomic EE-reared peers. Our results suggest distinct neural mechanisms for the generation and rescue of healthy and pathological brain synchrony, respectively, by EE and put forward hippocampal-prefrontal hypersynchrony and miscommunication as major targets underlying the beneficial effects of EE in intellectual disability.
Grants:	Agencia Estatal de Investigación PID2019-104683RB-I00 Agencia Estatal de Investigación SAF2016-80726-R
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Intellectual disability ; Down syndrome ; Prefrontal cortex ; Hippocampus ; Functional connectivity ; Cognitive stimulation ; Neural synchrony ; Ts65Dn Genetic mouse model ; Memory impairmentREM sleep
Published in:	Neurobiology of Disease, Vol. 173 (Oct. 2022) , art. 105841, ISSN 1095-953X

DOI: 10.1016/j.nbd.2022.105841

15 p, 6.9 MB

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Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Catalan Institute of Nanoscience and Nanotechnology (ICN2)
Articles > Research articles
Articles > Published articles