Shape analysis of subcortical structures in obsessive-compulsive disorder and the relationship with comorbid anxiety, depression, and medication use : A meta-analysis by the OCD Brain Imaging Consortium
Fouche, Jean-Paul (University of Cape Town)
Groenewold, Nynke A. (University of Cape Town)
Sevenoaks, Tatum (University of Cape Town)
Heany, Sarah (University of Cape Town)
Lochner, Christine (Stellenbosch University)
Alonso, Pino (Universitat de Barcelona)
Batistuzzo, Marcelo C. (Pontifical Catholic University)
Cardoner, N. (Narcís) (Universitat Autònoma de Barcelona)
Ching, Christopher R. K (Keck School of Medicine of USC)
de Wit, Stella J. (Vrije Universiteit)
Gutman, Boris A (Illinois Institute of Technology)
Hoexter, Marcelo Q. (University of Sao Paulo Medical School)
Jahanshad, Neda (Keck School of Medicine of USC)
Kim, Minah (Seoul National University College of Medicine)
Kwon, Jun Soo (Seoul National University)
Mataix-Cols, David (Karolinska Institutet (Estocolm, Suècia))
Menchón Magriñá, José Manuel (Universitat de Barcelona. Departament de Ciències Clíniques)
Miguel, Euripedes C. (University of Sao Paulo Medical School)
Nakamae, Takashi (Kyoto Prefectural University of Medicine)
Phillips, Mary L. (University of Pittsburgh School of Medicine)
Pujol Nuez, Jesús (Hospital del Mar (Barcelona, Catalunya))
Sakai, Yuki (ATR Brain Information Communication Research Laboratory Group)
Yun, Je-Yeon (Seoul National University College of Medicine)
Soriano-Mas, Carles (Universitat de Barcelona)
Thompson, Paul M. (Keck School of Medicine of USC)
Yamada, Kei (Kyoto Prefectural University of Medicine)
Veltman, Dick J. (Vrije Universiteit)
van den Heuvel, Odile A. (Vrije Universiteit)
Stein, Dan J. (Stellenbosch University)

Data:	2022
Resum:	Neuroimaging studies of obsessive-compulsive disorder (OCD) patients have highlighted the important role of deep gray matter structures. Less work has however focused on subcortical shape in OCD patients. Here we pooled brain MRI scans from 412 OCD patients and 368 controls to perform a meta-analysis utilizing the ENIGMA-Shape protocol. In addition, we investigated modulating effects of medication status, comorbid anxiety or depression, and disease duration on subcortical shape. There was no significant difference in shape thickness or surface area between OCD patients and healthy controls. For the subgroup analyses, OCD patients with comorbid depression or anxiety had lower thickness of the hippocampus and caudate nucleus and higher thickness of the putamen and pallidum compared to controls. OCD patients with comorbid depression had lower shape surface area in the thalamus, caudate nucleus, putamen, hippocampus, and nucleus accumbens and higher shape surface area in the pallidum. OCD patients with comorbid anxiety had lower shape surface area in the putamen and the left caudate nucleus and higher shape surface area in the pallidum and the right caudate nucleus. Further, OCD patients on medication had lower shape thickness of the putamen, thalamus, and hippocampus and higher thickness of the pallidum and caudate nucleus, as well as lower shape surface area in the hippocampus and amygdala and higher surface area in the putamen, pallidum, and caudate nucleus compared to controls. There were no significant differences between OCD patients without co-morbid anxiety and/or depression and healthy controls on shape measures. In addition, there were also no significant differences between OCD patients not using medication and healthy controls. The findings here are partly consistent with prior work on brain volumes in OCD, insofar as they emphasize that alterations in subcortical brain morphology are associated with comorbidity and medication status. Further work is needed to understand the biological processes contributing to subcortical shape. There is a paucity of literature on subcortical shape in OCD patients. In this multi-site meta-analysis there was no significant difference in shape between OCD patients and controls, however abnormalities in both shape thickness and surface area were found for medicated OCD patients with comorbid anxiety and depression compared to healthy controls.
Ajuts:	Instituto de Salud Carlos III PI18/00856 Ministerio de Economía y Competitividad PI16/00889 Generalitat de Catalunya PERISSLT006/17/00249
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Anxiety ; Depression ; Gray matter ; Magnetic resonance imaging ; Neuroimaging ; Obsessive-compulsive disorder ; Subcortical
Publicat a:	Brain and behavior, Vol. 12 (september 2022) , ISSN 2162-3279

DOI: 10.1002/brb3.2755
PMID: 36106505

12 p, 568.9 KB

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