Polygenic association between attention-deficit/hyperactivity disorder liability and cognitive impairments
Vainieri, Isabella (Institute of Psychiatry (Regne Unit))
Martin, Joanna (Cardiff University (Regne Unit))
Rommel, Anna-Sophie (Public Health at the Icahn School of Medicine at Mount Sinai)
Asherson, Philip (King's College London)
Banaschewski, Tobias (University of Heidelberg)
Buitelaar, Jan (Radboud University Medical Centre)
Cormand, Bru (Institut de Recerca Sant Joan de Déu)
Crosbie, Jennifer (University of Toronto)
Faraone, Stephen V. (SUNY Upstate Medical University)
Franke, Barbara (Radboud University Medical Center)
Loo, Sandra K. (Semel Institute for Neuroscience and Human Behavior and David Geffen School of Medicine at UCLA)
Miranda, Ana (Universitat de València)
Manor, Iris (Tel-Aviv University)
Oades, Robert D. (University of Duisburg-Essen)
Purves, Kirstin L. (Institute of Psychiatry, Psychology and Neuroscience)
Ramos-Quiroga, Josep Antoni (Universitat Autònoma de Barcelona)
Ribasés Haro, Marta (Universitat de Barcelona)
Roeyers, Herbert (Ghent University)
Rothenberger, Aribert (University Medical Center Göttingen)
Schachar, Russell (University of Toronto)
Sergeant, Joseph (Vrije Universiteit)
Steinhausen, Hans-Christoph (Centre of Child and Adolescent Mental Health)
Vuijk, Pieter J. (Massachusetts General Hospital (Boston))
Doyle, Alysa E. (Harvard Medical School)
Kuntsi, Jonna (King's College London. Institute of Psychiatry, Psychology & Neuroscience)

Fecha:	2022
Resumen:	A recent genome-wide association study (GWAS) identified 12 independent loci significantly associated with attention-deficit/hyperactivity disorder (ADHD). Polygenic risk scores (PRS), derived from the GWAS, can be used to assess genetic overlap between ADHD and other traits. Using ADHD samples from several international sites, we derived PRS for ADHD from the recent GWAS to test whether genetic variants that contribute to ADHD also influence two cognitive functions that show strong association with ADHD: attention regulation and response inhibition, captured by reaction time variability (RTV) and commission errors (CE). The discovery GWAS included 19 099 ADHD cases and 34 194 control participants. The combined target sample included 845 people with ADHD (age: 8-40 years). RTV and CE were available from reaction time and response inhibition tasks. ADHD PRS were calculated from the GWAS using a leave-one-study-out approach. Regression analyses were run to investigate whether ADHD PRS were associated with CE and RTV. Results across sites were combined via random effect meta-analyses. When combining the studies in meta-analyses, results were significant for RTV (R 2 = 0. 011, β = 0. 088, p = 0. 02) but not for CE (R 2 = 0. 011, β = 0. 013, p = 0. 732). No significant association was found between ADHD PRS and RTV or CE in any sample individually (p > 0. 10). We detected a significant association between PRS for ADHD and RTV (but not CE) in individuals with ADHD, suggesting that common genetic risk variants for ADHD influence attention regulation.
Ayudas:	Ministerio de Ciencia e Innovación CP09/00119 Ministerio de Economía y Competitividad CPII15/00023 Ministerio de Economía y Competitividad PI16/01505 Instituto de Salud Carlos III PI17/00289 Instituto de Salud Carlos III PI18/01788 Instituto de Salud Carlos III PI19/00721 Instituto de Salud Carlos III PI19/01224 Agència de Gestió d'Ajuts Universitaris i de Recerca 2017SGR1461
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	ADHD ; Attention ; Cognition ; Inhibition ; Polygenic risk scores ; Reaction time variability
Publicado en:	Psychological Medicine, Vol. 52 (october 2022) , p. 3150-3158, ISSN 1469-8978

DOI: 10.1017/S0033291720005218
PMID: 33531098

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