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Página principal > Artículos > Artículos publicados > Quantifying In-Host Quasispecies Evolution |
Fecha: | 2023 |
Resumen: | What takes decades, centuries or millennia to happen with a natural ecosystem, it takes only days, weeks or months with a replicating viral quasispecies in a host, especially when under treatment. Some methods to quantify the evolution of a quasispecies are introduced and discussed, along with simple simulated examples to help in the interpretation and understanding of the results. The proposed methods treat the molecules in a quasispecies as individuals of competing species in an ecosystem, where the haplotypes are the competing species, and the ecosystem is the quasispecies in a host, and the evolution of the system is quantified by monitoring changes in haplotype frequencies. The correlation between the proposed indices is also discussed, and the R code used to generate the simulations, the data and the plots is provided. The virtues of the proposed indices are finally shown on a clinical case. |
Ayudas: | Ministerio de Economía y Competitividad RD16/0016/0003 Ministerio de Economía y Competitividad IDI-20200297 Instituto de Salud Carlos III PI19/00301 Instituto de Salud Carlos III PI22/00258 |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Quasispecies evolution ; Distributions similarity ; Quasispecies fitness partition ; Viral treatment ; Mutagenesis |
Publicado en: | International journal of molecular sciences, Vol. 24 (january 2023) , ISSN 1422-0067 |
16 p, 586.7 KB |