Characteristics of Induced-Sputum Inflammatory Phenotypes in Adults with Asthma : Predictors of Bronchial Eosinophilia
Crespo Lessmann, Astrid ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina)
Curto Sánchez, Elena ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina)
Mateus Medina, Eder Freddy (Universitat Autònoma de Barcelona. Departament de Medicina)
Palones, Esther ![Identificador ORCID](/img/uab/orcid.ico)
(Universitat Autònoma de Barcelona. Departament de Medicina)
Belda Soler, Alicia (Universitat Autònoma de Barcelona. Departament de Medicina)
Sánchez Maza, Soraya (Universitat Autònoma de Barcelona. Departament de Medicina)
Soto-Retes, Lorena
(Universitat Autònoma de Barcelona. Departament de Medicina)
Plaza, Vicente
(Universitat Autònoma de Barcelona. Departament de Medicina)
Fecha: |
2023 |
Resumen: |
The objectives of this study were, for patients attending a specialist asthma clinic at a tertiary care hospital, to determine, from sputum induction (SI), proportions of bronchial inflammatory phenotypes, demographic, clinical and functional characteristics of each phenotype, and the most accessible non-invasive inflammatory marker that best discriminates between phenotypes. Included were 96 patients with asthma, attending a specialist asthma clinic at a tertiary care hospital, who underwent testing as follows: SI, spirometry, fractional exhaled nitric oxide (FeNO), blood eosinophilia, total immunoglobulin E (IgE), and a skin prick test. SI phenotypes were 46. 9% eosinophilic, 33. 3% paucigranulocytic, 15. 6% neutrophilic, and 4. 2% mixed. No significantly different clinical or functional characteristics were observed between the phenotypes. A positive correlation was observed between SI eosinophilia and both emergency visits in the last 12 months (p = 0. 041; r = 0. 214) and FeNO values (p = 0. 000; r = 0. 368). Blood eosinophilia correlated with SI eosinophilia (p = 0. 001; r = 0. 362) and was the best predictor of bronchial eosinophilia, followed by FeNO, and total blood IgE (area under the receiver operating characteristic curve (AUC-ROC) 72%, 65%, and 53%, respectively), although precision was only fair. In consultations for severe asthma, the most frequent phenotype was eosinophilic. Peripheral blood eosinophilia is a reliable marker for discriminating between different bronchial inflammatory phenotypes, is useful in enabling doctors to select a suitable biologic treatment and so prevent asthma exacerbation, and is a better predictor of bronchial eosinophilia than FeNO and IgE values. |
Derechos: |
Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. ![Creative Commons](/img/licenses/by-nc.ico) |
Lengua: |
Anglès |
Documento: |
Article ; recerca ; Versió publicada |
Materia: |
Asthma ;
Sputum induction ;
Phenotype ;
Eosinophilia |
Publicado en: |
Journal of Asthma and Allergy, Vol. 16 (january 2023) , p. 95-103, ISSN 1178-6965 |
DOI: 10.2147/JAA.S389402
PMID: 36699564
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Registro creado el 2023-02-02, última modificación el 2024-02-08