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Página principal > Artículos > Artículos publicados > Long-term antibiotic therapy in patients with surgery-indicated not undergoing surgery infective endocarditis |
Fecha: | 2021 |
Resumen: | Background: To date, there is little information regarding management of patients with infective endocarditis (IE) that did not undergo an indicated surgery. Therefore, we aimed to evaluate prognosis of these patients treated with a long-term antibiotic treatment strategy, including oral long term suppressive antibiotic treatment in five referral centres with a multidisciplinary endocarditis team. Methods: This retrospective, multicenter study retrieved individual patient-level data from five referral centres in Spain. Among a total of 1797, 32 consecutive patients with IE were examined (median age 72 years; 78% males) who had not undergone an indicated surgery, but received long-term antibiotic treatment (LTAT) and were followed by a multidisciplinary endocarditis team, between 2011 and 2019. Primary outcomes were infection relapse and mortality during follow-up. Results: Among 32 patients, 21 had IE associated with prostheses. Of the latter, 8 had an ascending aorta prosthetic graft. In 24 patients, a switch to long-term oral suppressive antibiotic treatment (LOSAT) was considered. The median duration of LOSAT was 277 days. Four patients experienced a relapse during follow-up. One patient died within 60 days, and 12 patients died between 60 days and 3 years. However, only 4 deaths were related to IE. Conclusions: The present study results suggest that a LTAT strategy, including LOSAT, might be considered for patients with IE that cannot undergo an indicated surgery. After hospitalization, they should be followed by a multidisciplinary endocarditis team. |
Ayudas: | Ministerio de Economía y Competitividad SAF2014-59892 Instituto de Salud Carlos III CB16/11/00403 Instituto de Salud Carlos III JR17/00006 |
Nota: | Altres ajuts: Fundació La MARATÓ de TV3 (201502, 201516); CIBER Cardiovascular; AdvanceCat 2014. |
Derechos: | Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades. |
Lengua: | Anglès |
Documento: | Article ; recerca ; Versió publicada |
Materia: | Suppressive antibiotic treatment ; Infective endocarditis ; Surgery |
Publicado en: | Cardiology Journal, Vol. 28 Núm. 4 (2021) , p. 566-578, ISSN 1898-018X |
13 p, 254.3 KB |