Biopsychosocial Response to the COVID-19 Lockdown in People with Major Depressive Disorder and Multiple Sclerosis
Siddi, Sara (Parc Sanitari Sant Joan de Déu)
Giné-Vázquez, Iago (Parc Sanitari Sant Joan de Déu)
Bailón, Raquel (Universidad de Zaragoza)
Matcham, Faith (University of Sussex)
Lamers, Femke (Amsterdam Public Health Research Institute)
Kontaxis, Spyridon (Centros de Investigación Biomédica en Red en el Área de Bioingeniería)
Laporta, Estela (Centros de Investigación Biomédica en Red en el Área de Bioingeniería)
Garcia, Esther (Universitat Autònoma de Barcelona. Departament de Microelectrònica i Sistemes Electrònics)
Arranz, Belén (Parc Sanitari Sant Joan de Déu)
Dalla Costa, Giancarlo (Vita-Salute San Raffaele University)
Guerrero, Ana Isabel (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Zabalza, Ana (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Buron, Mathias Due (Copenhagen University Hospital Rigshospitalet)
Comi, Giancarlo (Vita-Salute San Raffaele University)
Leocani, Letizia (Scientific Institute San Raffaele)
Annas, Peter (H. Lundbeck A/S)
Hotopf, Matthew (King's College London)
Penninx, Benda W. J. (Amsterdam Public Health Research Institute)
Magyari, Melinda (Copenhagen University Hospital Rigshospitalet)
Sørensen, Per S. (Copenhagen University Hospital Rigshospitalet)
Montalban, Xavier (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Lavelle, Grance (King's College London)
Ivan, Alina (King's College London)
Oetzmann, Carolin (King's College London)
White, katie M. (King's College London)
Difrancesco, Sonia (Vrije Universiteit)
Locatelli, Patrick (University of Bergamo)
Mohr, David C. (Northwestern University)
Aguiló Llobet, Jordi (Universitat Autònoma de Barcelona. Departament de Microelectrònica i Sistemes Electrònics)
Narayan, Vaibhav (Janssen Research Development)
Folarin, Amoros (King's College London)
Dobson, Richard J.B. (King's College London)
Dineley, Judith (King's College London)
Leightley, Daniel (King's College London)
Cummins, Nicholas (King's College London)
Vairavan, Srinivasan (Janssen Research Development)
Ranjan, Yathart (King's College London)
Rashid, Zulqarnain (King's College London)
Rintala, Aki (LAB University of Applied Sciences)
Girolamo, Giovanni De (IRCCS Instituto Centro San Giovanni di Dio Fatebenefratelli)
Preti, Antonio (Università degli Studi di Torino)
Simblett, Sara (King's College London)
Wykes, Til (King's College London)
Myin-Germeys, Inez (Katholieke Universiteit Leuven)
Haro Abad, Josep Maria (Parc Sanitari Sant Joan de Déu)

Date:	2022
Abstract:	Changes in lifestyle, finances and work status during COVID-19 lockdownsmay have led to biopsychosocial changes in people with pre-existing vulnerabilities such as MajorDepressive Disorders (MDDs) and Multiple Sclerosis (MS). Methods: Data were collected as a part the RADAR-CNS (Remote Assessment of Disease and Relapse-Central Nervous System) program. We analyzed the following data from long-term participants in a decentralized multinational study:J. Clin. Med. 2022, 11, 7163. https://doi. org/10. 3390/jcm11237163 https://www. mdpi. com/journal/jcm J. Clin. Med. 2022, 11, 7163 2 of 20 symptoms of depression, heart rate (HR) during the day and night; social activity; sedentary state,steps and physical activity of varying intensity. Linear mixed-effects regression analyses with repeated measures were fitted to assess the changes among three time periods (pre, during and post-lockdown) across the groups, adjusting for depression severity before the pandemic and gender. Results: Participants with MDDs (N = 255) and MS (N = 214) were included in the analyses. Overall,depressive symptoms remained stable across the three periods in both groups. A lower mean HR and HR variation were observed between pre and during lockdown during the day for MDDs and during the night for MS. HR variation during rest periods also decreased between pre- and post-lockdown in both clinical conditions. We observed a reduction in physical activity for MDDs and MS upon the introduction of lockdowns. The group with MDDs exhibited a net increase in social interaction via social network apps over the three periods. Conclusions: Behavioral responses to the lockdown measured by social activity, physical activity and HR may reflect changes in stress in people with MDDs and MS. Remote technology monitoring might promptly activate an early warning of physical and social alterations in these stressful situations. Future studies must explore how stress does or does not impact depression severity.
Grants:	European Commission. Horizon 2020 115902
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Published in:	Journal of clinical medicine, Vol. 11 Núm. 23 (december 2022) , p. 7163, ISSN 2077-0383

DOI: 10.3390/jcm11237163
PMID: 36498739

20 p, 2.4 MB

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