Death in hospital following ICU discharge : insights from the LUNG SAFE study
Madotto, Fabiana (IRCCS MultiMedica (Milà, Itàlia))
McNicholas, Bairbre (School of Medicine. Clinical Sciences Institute. National University of Ireland (Galway, Irlanda))
Rezoagli, Emanuele (San Gerardo Hospital. Department of Emergency and Intensive Care (Monza, Itàlia))
Pham, Tài (Hôpitaux Universitaires Paris-Saclay, Hôpital de Bicêtre, APHP, Le Kremlin-Bicêtre (França))
Laffey, John (Galway University Hospitals. Department of Anaesthesia and Intensive Care Medicine (Galway, Irlanda))
Bellani, Giacomo (San Gerardo Hospital. Department of Emergency and Intensive Care (Monza, Itàlia)/ LUNG SAFE (Itàlia))
The LUNG SAFE Investigators
The ESICM Trials GROUP

Fecha:	2021
Resumen:	Background: To determine the frequency of, and factors associated with, death in hospital following ICU discharge to the ward. Methods: The Large observational study to UNderstand the Global impact of Severe Acute respiratory FailurE study was an international, multicenter, prospective cohort study of patients with severe respiratory failure, conducted across 459 ICUs from 50 countries globally. This study aimed to understand the frequency and factors associated with death in hospital in patients who survived their ICU stay. We examined outcomes in the subpopulation discharged with no limitations of life sustaining treatments ('treatment limitations'), and the subpopulations with treatment limitations. Results: 2186 (94%) patients with no treatment limitations discharged from ICU survived, while 142 (6%) died in hospital. 118 (61%) of patients with treatment limitations survived while 77 (39%) patients died in hospital. Patients without treatment limitations that died in hospital after ICU discharge were older, more likely to have COPD, immunocompromise or chronic renal failure, less likely to have trauma as a risk factor for ARDS. Patients that died post ICU discharge were less likely to receive neuromuscular blockade, or to receive any adjunctive measure, and had a higher pre- ICU discharge non-pulmonary SOFA score. A similar pattern was seen in patients with treatment limitations that died in hospital following ICU discharge. Conclusions: A significant proportion of patients die in hospital following discharge from ICU, with higher mortality in patients with limitations of life-sustaining treatments in place. Non-survivors had higher systemic illness severity scores at ICU discharge than survivors. Trial Registration: ClinicalTrials. gov NCT02010073.
Nota:	Altres ajuts: Italian Ministry of University and Research (MIUR)-Department of Excellence project PREMIA (PREcision MedIcine Approach: bringing biomarker research to clinic); Science Foundation Ireland Future Research Leaders Award; European Society of Intensive Care Medicine (ESICM), Brussels; St Michael's Hospital, Toronto; University of Milan-Bicocca, Monza, Italy.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	Acute hypoxemic respiratory failure ; Acute respiratory distress syndrome ; Hospital survival ; ICU discharge ; Lung safe
Publicado en:	Critical care, Vol. 25 Núm. 1 (december 2021) , p. 144, ISSN 1466-609X

DOI: 10.1186/s13054-021-03465-0
PMID: 33849625

17 p, 1.4 MB

El registro aparece en las colecciones:
Documentos de investigación > Documentos de los grupos de investigación de la UAB > Centros y grupos de investigación (producción científica) > Ciencias de la salud y biociencias > Institut de Recerca Sant Pau
Artículos > Artículos de investigación
Artículos > Artículos publicados