Effect of age and sex on acenocoumarol requirements
Arboix Arzo, Margarita (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Laporte Rosselló, Joan-Ramón (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Frati, Maria Elisa (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)
Rutllan, M. (Universitat Autònoma de Barcelona. Departament de Farmacologia, de Terapèutica i de Toxicologia)

Data:	1984
Resum:	A group of 690 patients (337 males and 353 females) on long-term acenocoumarol therapy was studied. 62. 8% of the values of the prothrombin ratio were within the chosen therapeutic range (1. 8 to 2. 7), 21. 9% were below 1. 8 and 15. 3% were above 2. 7. The daily maintenance dose, expressed on a weight basis, was found to significantly decrease with increasing age. The daily maintenance dose taken by females was significantly higher than the dose taken by males (P less than 0. 05); the differences between males and females were maximal among patients aged between 21 and 50 years, and disappeared at older ages. Two hundred and twenty-eight haemorrhagic episodes in 160 patients were recorded during a total of 7797 months of follow-up. No lethal haemorrhages were observed. The overall incidence of bleeding episodes among females (3. 6%) was higher than among males (2. 2%) (P less than 0. 001), even if menorrhagia was excluded (P less than 0. 01). 1984 The British Pharmacological Society.
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Acenocoumarol ; Age ; Gender
Publicat a:	British Journal of Clinical Pharmacology, Vol. 18 Núm. 4 (october 1984) , p. 475-479, ISSN 1365-2125

DOI: 10.1111/j.1365-2125.1984.tb02494.x
PMID: 6487488

5 p, 2.1 MB

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