Novel strategies in nephrology : what to expect from the future?
Copur, Sidar (Koc University School of Medicine)
Tanriover, Cem (Koc University School of Medicine)
Yavuz, Furkan (Koc University School of Medicine)
Soler Aznar, Maria (Hospital Universitari Vall d'Hebron)
Ortiz, Alberto (Universidad Autónoma de Madrid)
Covic, Adrian (Nephrology Clinic (Romania))
Kanbay, Mehmet (Koc University School of Medicine)
Universitat Autònoma de Barcelona

Date:	2022
Abstract:	Chronic kidney disease (CKD) will become the fifth global case of death by 2040. Its largest impact is on premature mortality but the number of persons with kidney failure requiring renal replacement therapy (RRT) is also increasing dramatically. Current RRT is suboptimal due to the shortage of kidney donors and dismal outcomes associated with both hemodialysis and peritoneal dialysis. Kidney care needs a revolution. In this review, we provide an update on emerging knowledge and technologies that will allow an earlier diagnosis of CKD, addressing the current so-called blind spot (e. g. imaging and biomarkers), and improve renal replacement therapies (wearable artificial kidneys, xenotransplantation, stem cell-derived therapies, bioengineered and bio-artificial kidneys).
Grants:	Instituto de Salud Carlos III PI18/01366 Instituto de Salud Carlos III PI19/00588 Instituto de Salud Carlos III PI19/00815 Instituto de Salud Carlos III DTS18/00032 Instituto de Salud Carlos III AC18/00064 Instituto de Salud Carlos III AC18/00071 Instituto de Salud Carlos III PMP21/00109
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Artificial kidney ; Bioengineering ; Chronic kidney disease ; Induced pluripotent stem cells ; Xenotransplantation
Published in:	Clinical Kidney Journal, Vol. 16 (september 2022) , p. 230-244, ISSN 2048-8513

DOI: 10.1093/ckj/sfac212
PMID: 36755838

15 p, 1.1 MB

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