A self-powered skin-patch electrochromic biosensor
Santiago, Sara (Universitat Autònoma de Barcelona)
Río-Colín, Diego (Universidad del País Vasco)
Azizkhani, Haniyeh (Universitat Autònoma de Barcelona)
Aller Pellitero, Miguel (Johns Hopkins University School of Medicine)
Guirado López, Gonzalo (Universitat Autònoma de Barcelona)
del Campo, F. Javier (Institut de Microelectrònica de Barcelona)

Date:	2021
Abstract:	One of the limitations of many skin-patch wearable sensors today is their dependence on silicon-based electronics, increasing their complexity and unit cost. Self-powered sensors, in combination with electrochromic materials, allow simplifying the construction of these devices, leading to powerful analytical tools that remove the need for external detection systems. This work describes the construction, by screen-printing, of a self-powered electrochromic device that can be adapted for the determination of metabolites in sweat by the naked eye in the form of a 3 × 15 mm colour bar. The device comprises a lactate oxidase and osmium-polymer -based anode connected to a coplanar 3 × 15 mm Prussian Blue, PB, cathode printed over a transparent poly(3,4-ethylenedioxythiophene) polystyrene sulfonate, PEDOT:PSS electrode. An ion-gel composed of Poly(vinylidene fluoride-co-hexafluoropropylene), PVDF-co-HFP, a gelling agent, and ionic liquid 1-Ethyl-3-methylimidazolium trifluoromethanesulfonate, EMIM-Tf, effectively separates the cathode display from the biosensing anode, protecting it from the sample. Despite its cathodic electrochromism, the PEDOT:PSS has a transmission above 90% and does not mask the Prussian Blue colour change because the cathode does not operate below 0 V vs Ag/AgCl at any time. The sensor displays lactate concentrations in the range of 0-10 mM over the length of the electrochromic display, which has a contrast ratio of 1. 43. Although full response takes up to 24 min, 85% of the colour change is displayed within 10 min.
Grants:	Agència de Gestió d'Ajuts Universitaris i de Recerca PROD-0000114 Agencia Estatal de Investigación PID2019-106171RB-I00
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió acceptada per publicar
Subject:	Electrochromism ; Biosensors ; Self-powered devices ; Wearables ; Lactate biosensor ; Sweat sensing
Published in:	Biosensors & bioelectronics, Vol. 175 (March 2021) , art. 112879, ISSN 1873-4235

DOI: 10.1016/j.bios.2020.112879
PMID: 33309218

Postprint 25 p, 6.0 MB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Experimental sciences > Group in Electrochemistry, Photochemistry and Organic Reactivity (GEFRO)
Articles > Research articles
Articles > Published articles