Protocol for a randomized controlled multicenter trial assessing the efficacy of leuprorelin for severe polycystic liver disease : the AGAINST-PLD study - Aapkes, S.E. (Department of Nephrology. University Medical Center Groningen. University of Groningen) ; Bernts, L.H.P. (Department of Gastroenterology and Hepatology. Radboud University Medical Center) ; van den Berg, A.P. (Department of Gastroenterology and Hepatology. University Medical Center Groningen. University of Groningen) ; van den Berg, M. (Department of Obstetrics and Gynecology. University Medical Center Groningen. University of Groningen) ; Blokzijl, H. (Department of Gastroenterology and Hepatology. University Medical Center Groningen. University of Groningen) ; Cantineau, Astrid E P (Department of Obstetrics and Gynecology. University Medical Center Groningen. University of Groningen) ; van Gastel, M.D.A. (Department of Nephrology. University Medical Center Groningen. University of Groningen) ; de Haas, R.J. (Department of Radiology. University Medical Center Groningen. University of Groningen) ; Kappert, P. (Department of Radiology. University Medical Center Groningen. University of Groningen) ; Müller, R.U. (Department II of Internal Medicine and Center for Molecular Medicine Cologne. Faculty of Medicine. University Hospital Cologne. University of Cologne) ; Nevens, F. (Department of Gastroenterology and Hepatology. Universiteitsziekenhuis Leuven) ; Torra Balcells, Roser (Institut d'Investigació Biomèdica Sant Pau) ; Visser, A. (Department of Applied Health Sciences. University Medical Center Groningen. University of Groningen) ; Drenth, J.P.H. (Department of Gastroenterology and Hepatology. Radboud University Medical Center) ; Gansevoort, R.T. (Department of Nephrology. University Medical Center Groningen. University of Groningen)