Prognostic Impact of Nutritional Status After Transcatheter Edge-to-Edge Mitral Valve Repair : The MIVNUT Registry
Caneiro-Queija, Berenice (Instituto de Investigación Sanitaria Galicia Sur)
Raposeiras-Roubin, Sergio (Instituto de Investigación Sanitaria Galicia Sur)
Adamo, Marianna (Cardiac Catheteterization Laboratory. Cardiothoracic Department)
Freixa, Xavier (Hospital Clínic i Provincial de Barcelona)
Arzamendi, Dabit (Institut d'Investigació Biomèdica Sant Pau)
Benito-González, Tomás (Complejo Asistencial Universitario de León)
Montefusco, Antonio (University of Turin. Department of Medical Science)
Pascual, Isaaac (Hospital Universitario Central de Asturias)
Nombela-Franco, Luís (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Rodes-Cabau, Josep (Laval University)
Shuvy, Mony (Heart Institute. Hadassah-Hebrew University Medical Center)
Portolés-Hernández, Antonio (Heart Institute. Hadassah-Hebrew University Medical Center)
Godino, Cosmo (Complejo Asistencial Universitario de León)
Haberman, Dan (Kaplan Medical Center)
Lupi, Laura (Cardiac Catheteterization Laboratory. Cardiothoracic Department)
Regueiro, Ander (Hospital Clínic i Provincial de Barcelona)
Li, Chi Hion (Institut d'Investigació Biomèdica Sant Pau)
Fernández-Vázquez, Felipe (Complejo Asistencial Universitario de León)
Frea, Simone (Division of Cardiology. Department of Medical Science. University of Turin. Città della Salute e Della Scienza)
Avanzas, Pablo (Hospital Universitario Central de Asturias)
Tirado-Conte, Gabriela (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Paradis, Jean-Michel (Cardiology Department. Quebec Heart and Lung Institute. Laval University)
Peretz, Alona (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Moñivas, Vanessa (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Baz, Jose A. (Instituto de Investigación Sanitaria Galicia Sur)
Galasso, Michele (Instituto de Investigación Sanitaria Galicia Sur)
Branca, Luca (Cardiac Catheteterization Laboratory. Cardiothoracic Department)
Sanchís, Laura (Hospital Clínic i Provincial de Barcelona)
Asmarats, Lluís (Institut d'Investigació Biomèdica Sant Pau)
Garrote-Coloma, Carmen (IRCCS San Raffaele Scientific Institute (Milà, Itàlia))
Angelini, Filippo (Division of Cardiology. Department of Medical Science. University of Turin. Città della Salute e Della Scienza)
León, Victor (Hospital Universitario Central de Asturias)
Agustin, Jose Alberto de (Instituto de Investigación Sanitaria del Hospital Clínico San Carlos)
Alperi, Alberto (Cardiology Department. Quebec Heart and Lung Institute. Laval University)
Beeri, Ronen (Heart Institute. Hadassah-Hebrew University Medical Center)
Maccagni, Gloria (Cardiac Catheteterization Laboratory. Cardiothoracic Department)
Sabaté, Manel (Hospital Clínic i Provincial de Barcelona)
Fernández-Peregrina, Estefanía (Institut d'Investigació Biomèdica Sant Pau)
Gualis, Javier (Complejo Asistencial Universitario de León)
Bocchino, Pier Paolo (Division of Cardiology. Department of Medical Science. University of Turin. Città della Salute e Della Scienza)
Curello, Salvatore (Cardiac Catheteterization Laboratory. Cardiothoracic Department)
Íñiguez-Romo, Andrés (Instituto de Investigación Sanitaria Galicia Sur)
Estevez-Loureiro, Rodrigo (Instituto de Investigación Sanitaria Galicia Sur)

Fecha:	2022
Resumen:	BACKGROUND: Malnutrition is associated with poor prognosis in several cardiovascular diseases. However, its prognostic impact in patients undergoing transcatheter edge-to-edge mitral valve repair (TEER) is not well known. This study sought to assess the prevalence, clinical associations, and prognostic consequences of malnutrition in patients undergoing TEER. METHODS AND RESULTS: A total of 892 patients undergoing TEER from the international MIVNUT (Mitral Valve Repair and Nutritional Status) registry were studied. Malnutrition status was assessed with the Controlling Nutritional Status score. The association of nutritional status with mortality was analyzed with multivariable Cox regression models, whereas the association with heart failure admission was assessed by Fine-Gray models, with death as a competing risk. According to the Controlling Nutritional Status score, 74. 4% of patients with TEER had any degree of malnutrition at the time of TEER (75. 1% in patients with body mass index <25 kg/m, 72. 1% in those with body mass index ≥25 kg/m). However, only 20% had moderate-severe malnutrition. TEER was successful in most of patients (94. 2%). During a median follow-up of 1. 6 years (interquartile range, 0. 6-3. 0), 267 (29. 9%) patients died and 256 patients (28. 7%) were admitted for heart failure after TEER. Compared with normal nutritional status moderate-severe malnutrition resulted a strong predictor of mortality (adjusted hazard ratio [HR], 2. 1 [95% CI, 1. 1-2. 4]; P<0. 001) and heart failure admission (adjusted subdistribution HR, 1. 6 [95% CI, 1. 1-2. 4]; P=0. 015). CONCLUSIONS: Malnutrition is common among patients submitted to TEER, and moderate-severe malnutrition is strongly associated with increased mortality and heart failure readmission. Assessment of nutritional status in these patients may help to improve risk stratification.
Derechos:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Lengua:	Anglès
Documento:	Article ; recerca ; Versió publicada
Materia:	CONUT ; Heart failure ; Malnutrition ; Mortality ; Transcatheter edge-to-edge repair
Publicado en:	Journal of the American Heart Association. Cardiovascular and cerebrovascular disease, Vol. 11 Núm. 20 (18 2022) , p. e023121, ISSN 2047-9980

DOI: 10.1161/JAHA.121.023121
PMID: 36216434

21 p, 2.5 MB

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