Relationship between jumping to conclusions and clinical outcomes in people at clinical high-risk for psychosis
Catalan, Ana (Hospital de Basurto (Bilbao, Biscaia))
Tognin, Stefania (South London and Maudsley NHS Foundation Trust)
Kempton, Matthew J. (National Institute for Health Research (NIHR))
Stahl, Daniel (King's College London)
Salazar de Pablo, Gonzalo (Hospital General Universitario Gregorio Marañón. Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM))
Nelson, Barnaby (University of Melbourne)
Pantelis, Christos (The University of Melbourne & Melbourne Health)
Riecher-Rössler, Anita (University of Basel)
Bressan, Rodrigo Affonseca (Universidade Federal de São Paulo - UNIFESP)
Barrantes-Vidal, Neus (Universitat Autònoma de Barcelona. Departament de Psicologia Clínica i de la Salut)
Krebs, Marie-Odile (Pôle Hospitalo Universitaire PEPIT C'JAAD)
Nordentoft, Merete (University of Copenhagen)
Ruhrmann, Stephan (University of Cologne)
Sachs, Gabriele (Medical University of Vienna)
Rutten, Bart P. F. (Maastricht University)
van Os, Jim (Universiteit Utrecht)
de Haan, Lieuwe (Amsterdam UMC)
van der Gaag, Mark (Parnassia Psychiatric Institute)
Valmaggia, Lucia R. (King's College London)
McGuire, Philip (Biomedical Research Centre (BRC))

Data:	2022
Resum:	Psychosis is associated with a reasoning bias, which manifests as a tendency to 'jump to conclusions'. We examined this bias in people at clinical high-risk for psychosis (CHR) and investigated its relationship with their clinical outcomes. In total, 303 CHR subjects and 57 healthy controls (HC) were included. Both groups were assessed at baseline, and after 1 and 2 years. A 'beads' task was used to assess reasoning bias. Symptoms and level of functioning were assessed using the Comprehensive Assessment of At-Risk Mental States scale (CAARMS) and the Global Assessment of Functioning (GAF), respectively. During follow up, 58 (16. 1%) of the CHR group developed psychosis (CHR-T), and 245 did not (CHR-NT). Logistic regressions, multilevel mixed models, and Cox regression were used to analyse the relationship between reasoning bias and transition to psychosis and level of functioning, at each time point. There was no association between reasoning bias at baseline and the subsequent onset of psychosis. However, when assessed after the transition to psychosis, CHR-T participants showed a greater tendency to jump to conclusions than CHR-NT and HC participants (55, 17, 17%; χ2 = 8. 13, p = 0. 012). There was a significant association between jumping to conclusions (JTC) at baseline and a reduced level of functioning at 2-year follow-up in the CHR group after adjusting for transition, gender, ethnicity, age, and IQ. In CHR participants, JTC at baseline was associated with adverse functioning at the follow-up. Interventions designed to improve JTC could be beneficial in the CHR population.
Ajuts:	Agencia Estatal de Investigación PSI2017-87512-C2-1-R
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	Functioning ; Psychosis ; Transition to psychosis ; Ultra high-risk
Publicat a:	Psychological Medicine, Vol. 52 (june 2022) , p. 1569-1577, ISSN 1469-8978

DOI: 10.1017/S0033291720003396
PMID: 33019957

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