HDL Function and Size in Patients with On-Target LDL Plasma Levels and a First-Onset ACS
Cordero, Alberto (Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV) (Madrid, Espanya))
Muñoz-García, Natàlia (Institut d'Investigació Biomèdica Sant Pau)
Padró, Teresa (Institut d'Investigació Biomèdica Sant Pau)
Vilahur, Gemma (Institut d'Investigació Biomèdica Sant Pau)
Bertomeu-González, Vicente (Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV) (Madrid, Espanya))
Escribano, David (Centro de Investigación Biomédica en Red de Enfermedades Cardiovasculares (CIBERCV) (Madrid, Espanya))
Flores, Emilio (Hospital Universitario San Juan de Alicante)
Zuazola, Pilar (Fundación FISABIO (València, Espanya))
Badimon, Lina (Universitat Autònoma de Barcelona. Institut Universitari Avedis Donabedian)

Data:	2023
Resum:	Patients admitted for acute coronary syndrome (ACS) usually have high cardiovascular risk scores with low levels of high-density lipoprotein cholesterol (HDL-C) and high low-density lipoprotein cholesterol (LDL-C) levels. Here, we investigated the role of lipoprotein functionality as well as particle number and size in patients with a first-onset ACS with on-target LDL-C levels. Ninety-seven patients with chest pain and first-onset ACS with LDL-C levels of 100 ± 4 mg/dL and non-HDL-C levels of 128 ± 4. 0 mg/dL were included in the study. Patients were categorized as ACS and non-ACS after all diagnostic tests were performed (electrocardiogram, echocardiogram, troponin levels and angiography) on admission. HDL-C and LDL-C functionality and particle number/size by nuclear magnetic resonance (NMR) were blindly investigated. A group of matched healthy volunteers (n = 31) was included as a reference for these novel laboratory variables. LDL susceptibility to oxidation was higher and HDL-antioxidant capacity lower in the ACS patients than in the non-ACS individuals. ACS patients had lower HDL-C and Apolipoprotein A-I levels than non-ACS patients despite the same prevalence of classical cardiovascular risk factors. Cholesterol efflux potential was impaired only in the ACS patients. ACS-STEMI (Acute Coronary Syndrome-ST-segment-elevation myocardial infarction) patients, had a larger HDL particle diameter than non-ACS individuals (8. 4 ± 0. 02 vs. 8. 3 ± 0. 02 and, ANOVA test, p = 0. 004). In conclusion, patients admitted for chest pain with a first-onset ACS and on-target lipid levels had impaired lipoprotein functionality and NMR measured larger HDL particles. This study shows the relevance of HDL functionality rather than HDL-C concentration in ACS patients.
Ajuts:	Ministerio de Economía y Competitividad CB16/11/00411 Ministerio de Economía y Competitividad CB16/11/00226 Ministerio de Economía y Competitividad CB16/11/00420 Instituto de Salud Carlos III PI19/01687
Drets:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Llengua:	Anglès
Document:	Article ; recerca ; Versió publicada
Matèria:	ACS ; NSTEMI ; STEMI ; Lipoprotein functionality ; HDL-C ; LDL-C ; Cholesterol efflux
Publicat a:	International journal of molecular sciences, Vol. 24 (march 2023) , ISSN 1422-0067

DOI: 10.3390/ijms24065391
PMID: 36982465

13 p, 954.9 KB

El registre apareix a les col·leccions:
Articles > Articles de recerca
Articles > Articles publicats