A new Therapeutic approach based on a reinterpretation of asthma control
Pérez de Llano, Luis (Hospital Universitario Lucus Augusti (Lugo))
Entrenas Costa, Luis M (Hospital Universitario Reina Sofía (Còrdova, Espanya))
Carrascosa, M. Inés (Hospital de Urduliz Alfredo Espinosa)
Dávila, Ignacio (Hospital Clínico Universitario (Salamanca))
Almonacid, Carlos (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Abascal-Bolado, Beatriz (Hospital Universitario Marqués de Valdecilla (Santander, Cantabria))
Montoro, Francisco Javier (Hospital de Llíria, Valencia;)
Sogo, Ana Isabel (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))
Domingo, Christian (Parc Taulí Hospital Universitari. Institut d'Investigació i Innovació Parc Taulí (I3PT))

Date:	2023
Description:	12 pàg.
Abstract:	The concept of asthma control is fundamental because it establishes a target for treatment, but despite the diversity of definitions, a high proportion of patients fail to achieve it. In this article, we highlight the shortcomings of the current concept of control by discussing aspects such as the differences between patient- and physician-perceived control and the limitations of the tools used to assess it. We also comment on the drawbacks of the stepwise approach to achieve control recommended by guidelines: the absence of conclusive evidence on the exclusive use of as-needed budesonide/formoterol in mild asthma, the lack of consideration of the different pharmacological properties of the currently available inhaled corticosteroids (ICS) and ignoring the existence of different asthma endotypes, some of which are resistant to these drugs. Other aspects, such as adherence to medication, the use of rescue medication, the influence of the inhalation device, the particle size, the pharmacological characteristics, and the lung deposition of ICS, are also mentioned. As an alternative to the guidelines' recommendations, we propose a more customized approach based on the identification of therapeutic goals and treatable traits.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, i la comunicació pública de l'obra, sempre que no sigui amb finalitats comercials, i sempre que es reconegui l'autoria de l'obra original. No es permet la creació d'obres derivades.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Adherence ; Asthma control ; Inhaled corticosteroid ; Inhaler device ; Therapeutic index
Published in:	BRN Review, Vol. 9 Núm. 2 (2023) , ISSN 2462-3172

DOI: 10.23866/BRNRev:2023-M0089

12 p, 330.8 KB

The record appears in these collections:
Research literature > UAB research groups literature > Research Centres and Groups (research output) > Health sciences and biosciences > Parc Taulí Research and Innovation Institute (I3PT
Articles > Research articles
Articles > Published articles