Low Phase Angle Values Are Associated with Malnutrition according to the Global Leadership Initiative on Malnutrition Criteria in Kidney Transplant Candidates : Preliminary Assessment of Diagnostic Accuracy in the FRAILMar Study
Muñoz-Redondo, Elena (Institut Hospital del Mar d'Investigacions Mèdiques)
Morgado-Pérez, Andrea (Parc de Salut MAR de Barcelona)
Pérez-Sáez, María José (Hospital del Mar (Barcelona, Catalunya))
Faura, Anna (Hospital del Mar (Barcelona, Catalunya))
Sánchez-Rodríguez, Dolores (Parc de Salut MAR de Barcelona)
Tejero-Sánchez, Marta (Hospital del Mar (Barcelona, Catalunya))
Meza-Valderrama, Delky (Hospital del Mar (Barcelona, Catalunya))
Muns, María Dolors (Hospital del Mar (Barcelona, Catalunya))
Pascual, Julio (Hospital Universitario 12 de Octubre (Madrid))
Marco, Ester (Parc de Salut MAR de Barcelona)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Malnutrition has a negative impact on patients with chronic diseases and its early identification is a priority. The primary objective of this diagnostic accuracy study was to assess the performance of the phase angle (PhA), a bioimpedance analysis (BIA)-derived parameter, for malnutrition screening using the Global Leadership Initiative for Malnutrition (GLIM) criteria as the reference standard in patients with advanced chronic kidney disease (CKD) waiting for kidney transplantation (KT); criteria associated with low PhA in this population were also analyzed. Sensitivity, specificity, accuracy, positive and negative likelihood ratios, predictive values, and area under the receiver operating characteristic curve were calculated for PhA (index test) and compared with GLIM criteria (reference standard). Of 63 patients (62. 9 years old; 76. 2% men), 22 (34. 9%) had malnutrition. The PhA threshold with the highest accuracy was ≤4. 85° (sensitivity 72. 7%, specificity 65. 9%, and positive and negative likelihood ratios 2. 13 and 0. 41, respectively). A PhA ≤ 4. 85° was associated with a 3. 5-fold higher malnutrition risk (OR = 3. 53 (CI95% 1. 0-12. 1)). Considering the GLIM criteria as the reference standard, a PhA ≤ 4. 85° showed only fair validity for detecting malnutrition, and thus cannot be recommended as a stand-alone screening tool in this population.
Grants:	Instituto de Salud Carlos III PI19/00037
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Advanced chronic kidney disease ; GLIM ; Malnutrition ; Muscle mass ; Phase angle ; Prehabilitation
Published in:	Nutrients, Vol. 15 (february 2023) , ISSN 2072-6643

DOI: 10.3390/nu15051084
PMID: 36904084

13 p, 2.1 MB

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