The Conners Continuous Performance Test CPT3 ™ : Is it a reliable marker to predict neurocognitive dysfunction in Myalgic encephalomyelitis/chronic fatigue syndrome?
Fernández-Quirós, Judith (Hospital Universitari Vall d'Hebron)
Lacasa-Cazcarra, Marcos (Universitat Oberta de Catalunya)
Alegre Martín, José (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Sanmartin Sentañes, Ramon (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Almirall, Míriam (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Launois-Obregón, Patricia (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Castro-Marrero, Jesús (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Rodríguez-Urrutia, Amanda (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Navarro-Sanchis, Jose A. (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Ramos-Quiroga, Josep Antoni (Hospital Universitari Vall d'Hebron. Institut de Recerca)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	The main objective is to delimit the cognitive dysfunction associated with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) in adult patients by applying the Continuous Performance Test (CPT3 ™). Additionally, provide empirical evidence on the usefulness of this computerized neuropsychological test to assess ME/CFS. The final sample (n = 225; 158 Patients/67 Healthy controls) were recruited in a Central Sensitization Syndromes (CSS) specialized unit in a tertiary hospital. All participants were administered this neuropsychological test. There were significant differences between ME/CFS and healthy controls in all the main measures of CPT3 ™. Mainly, patients had a worse indicator of inattentiveness, sustained attention, vigilance, impulsivity, slow reaction time, and more atypical T-scores, which is associated with a likelihood of having a disorder characterized by attention deficits, such as Attention Deficit Hyperactivity Disorder (ADHD). In addition, relevant correlations were obtained between the CPT3 ™ variables in the patient's group. The most discriminative indicators of ME/CFS patients were Variability and Hit Reaction Time, both measures of response speed. The CPT3 ™ is a helpful tool to discriminate neurocognitive impairments from attention and response speed in ME/CFS patients, and it could be used as a marker of ME/CFS severity for diagnosing or monitoring this disease.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Neuropsychological test ; Cognitive impairments ; Continuous performance test ; CPT3 ™ ; Neurocognitive dysfunction ; Central Sensitization Syndromes ; Chronic fatigue syndrome
Published in:	Frontiers in psychology, Vol. 14 (february 2023) , ISSN 1664-1078

DOI: 10.3389/fpsyg.2023.1127193
PMID: 36923151

13 p, 1.5 MB

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