Bariatric Surgery Is Associated with Alcohol-Related Liver Disease and Psychiatric Disorders Associated with AUD
Alvarado-Tapias, Edilmar (Hospital de la Santa Creu i Sant Pau (Barcelona, Catalunya))
Marti-Aguado, David (Institut d'Investigació Biomèdica INCLIVA)
Kennedy, Kevin (Kansas City)
Fernández-Carrillo, Carlos (Hospital Universitario Puerta de Hierro Majadahonda (Madrid))
Ventura-Cots, Meritxell (Hospital Universitari Vall d'Hebron)
Morales-Arraez, Dalia (Hospital Universitario de Canarias (La Laguna))
Atkinson, Stephen R. (Imperial College London)
Clemente-Sanchez, Ana (Hospital General Universitario Gregorio Marañón)
Argemi, Josepmaria (Clínica Universidad de Navarra)
Bataller, Ramon (Universitat de Barcelona)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Bariatric surgery can increase the risk of addictive disorders and nutritional deficiencies. The aim of this study was to evaluate the association between bariatric surgery and alcohol use disorder (AUD), alcohol-related liver disease (ALD), and psychiatric disorders associated with AUD. The impact of vitamin D deficiency in these associations was also investigated. A cross-sectional study was performed using the National Inpatient Sample database and its ICD-9 codes information. Diagnostic and comorbidity data from hospital discharges were obtained from patients with bariatric surgery and other abdominal surgeries between 2005 and 2015. The two groups were then compared for alcohol-related outcomes after propensity-score matching. The final study cohort included 537,757 patients with bariatric surgery and 537,757 with other abdominal surgeries. The bariatric surgery group had an increased risk of AUD [odds ratio (OR): 1. 90; 95% CI: 1. 85-1. 95], ALD [OR: 1. 29; 95% CI: 1. 22-1. 37], cirrhosis [OR, 1. 39; 95% CI: 1. 37-1. 42], and psychiatric disorders associated with AUD [OR, 3. 59; 95% CI: 3. 37-3. 84]. Vitamin D deficiency did not impact in the association between bariatric surgery and AUD, ALD, or psychiatric disorders associated with AUD. Bariatric surgery is associated with an increased prevalence of AUD, ALD, and psychiatric disorders associated with AUD. These associations appear to be independent from vitamin D deficiency. The online version contains supplementary material available at 10. 1007/s11695-023-06490-w.
Grants:	Ministerio de Economía y Competitividad CM16/00133 Instituto de Salud Carlos III PI20/01663
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Alcohol-related liver disease ; Alcohol-related mental disorder ; Alcohol use disorder ; Bariatric surgery ; Vitamin D
Published in:	Obesity Surgery, Vol. 33 (march 2023) , p. 1494-1505, ISSN 1708-0428

DOI: 10.1007/s11695-023-06490-w
PMID: 36881347

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