Anti-U11/U12 Antibodies as a Rare but Important Biomarker in Patients with Systemic Sclerosis : A Narrative Review
Fritzler, Marvin J. (University of Calgary)
Bentow, Chelsea (Werfen)
Beretta, Lorenzo (Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico (Milà, Itàlia))
Palterer, Boaz (Università degli Studi di Firenze)
Perurena Prieto, Janire (Hospital Universitari Vall d'Hebron)
Sanz-Martínez, María Teresa (Hospital Universitari Vall d'Hebron)
Guillén-Del-Castillo, Alfredo (Hospital Universitari Vall d'Hebron)
Marín-Sánchez, Ana (Hospital Universitari Vall d'Hebron)
Fonollosa Pla, Vicent (Hospital Universitari Vall d'Hebron)
Callejas Moraga, Eduardo Luis (Hospital Público de Monforte)
Simeón-Aznar, Carmen Pilar (Hospital Universitari Vall d'Hebron)
Mahler, Michael (Werfen)
Universitat Autònoma de Barcelona

Date:	2023
Abstract:	Anti-nuclear (ANA) are present in approximately 90% of systemic sclerosis (SSc) patients and are key biomarkers in supporting the diagnosis and determining the prognosis of this disease. In addition to the classification criteria autoantibodies for SSc [i. e. , anti-centromere, anti-topoisomerase I (Scl-70), anti-RNA polymerase III], other autoantibodies have been associated with important SSc phenotypes. Among them, anti-U11/U12 ribonucleoprotein (RNP) antibodies, also known as anti-RNPC-3, were first reported in a patient with SSc, but very little is known about their association and clinical utility. The U11/U12 RNP macromolecular complex consists of several proteins involved in alternative mRNA splicing. More recent studies demonstrated associations of anti-anti-U11/U12 antibodies with SSc and severe pulmonary fibrosis as well as with moderate to severe gastrointestinal dysmotility. Lastly, anti-U11/U12 autoantibodies have been strongly associated with malignancy in SSc patients. Here, we aimed to summarize the knowledge of anti-U11/U12/RNPC-3 antibodies in SSc, including their seroclinical associations in a narrative literature review.
Rights:	Aquest document està subjecte a una llicència d'ús Creative Commons. Es permet la reproducció total o parcial, la distribució, la comunicació pública de l'obra i la creació d'obres derivades, fins i tot amb finalitats comercials, sempre i quan es reconegui l'autoria de l'obra original.
Language:	Anglès
Document:	Article ; recerca ; Versió publicada
Subject:	Autoantibodies ; Interstitial lung disease ; SSc ; Systemic sclerosis ; U11/U12
Published in:	Diagnostics, Vol. 13 (march 2023) , ISSN 2075-4418

DOI: 10.3390/diagnostics13071257
PMID: 37046475

13 p, 1.3 MB

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